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Bone remodeling effect of a chitosan and calcium phosphate-based composite
- Source :
- Regenerative Biomaterials
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Chitosan is a biocompatible polymer that has been widely studied for tissue engineering purposes. The aim of this research was to assess bone regenerative properties of an injectable chitosan and calcium phosphate-based composite and identify optimal degree of deacetylation (%DDA) of the chitosan polymer. Drill holes were generated on the left side of a mandible in Sprague-Dawley rats, and the hole was either left empty or filled with the implant. The animals were sacrificed at several time points after surgery (7–22 days) and bone was investigated using micro-CT and histology. No significant new bone formation was observed in the implants themselves at any time points. However, substantial new bone formation was observed in the rat mandible further away from the drill hole. Morphological changes indicating bone formation were found in specimens explanted on Day 7 in animals that received implant. Similar bone formation pattern was seen in control animals with an empty drill hole at later time points but not to the same extent. A second experiment was performed to examine if the %DDA of the chitosan polymer influenced the bone remodeling response. The results suggest that chitosan polymers with %DDA between 50 and 70% enhance the natural bone remodeling mechanism.
- Subjects :
- X-ray microtomography
degree of deacetylation
bone implant
chemistry.chemical_element
bone defects
02 engineering and technology
micro-CT
Calcium
Bone remodeling
Biomaterials
Chitosan
03 medical and health sciences
chemistry.chemical_compound
Tissue engineering
Research Articles
bone remodeling
030304 developmental biology
0303 health sciences
Mandible
Histology
021001 nanoscience & nanotechnology
rat mandible
chemistry
Implant
chitosan
0210 nano-technology
Biomedical engineering
Subjects
Details
- ISSN :
- 20563426 and 20563418
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Regenerative Biomaterials
- Accession number :
- edsair.doi.dedup.....49268f6d321b5329a41a22932b9ba1d4