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Oxidative stress: therapeutic approaches for cervical cancer treatment
- Source :
- Clinics; v. 73 n. Suppl. 1 (2018); e548s, Clinics; Vol. 73 Núm. Suppl. 1 (2018); e548s, Clinics; Vol. 73 No. Suppl. 1 (2018); e548s, Clinics, Universidade de São Paulo (USP), instacron:USP, Clinics, Vol 73, Iss suppl 1 (2018)
- Publication Year :
- 2018
-
Abstract
- OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. In this context, oxidative stress, chronic inflammation and high-risk human papillomavirus can act in a synergistic manner. To counteract the harmful effects of oxidant species, protective molecules, known as antioxidant defenses, are produced by cells to maintain redox homeostasis. In recent years, the use of natural antioxidants as therapeutic strategies for cancer treatment has attracted the attention of the scientific community. This review discusses specific molecules and mechanisms that can act against or together with oxidative stress, presenting alternatives for cervical cancer prevention and treatment.
- Subjects :
- 0301 basic medicine
Antioxidant
medicine.medical_treatment
Uterine Cervical Neoplasms
Context (language use)
Inflammation
Apoptosis
Review Article
medicine.disease_cause
Cervical Cancer
Antioxidants
Malignant transformation
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Human papillomavirus
Enzyme Inhibitors
Tumor Markers
Cervical cancer
chemistry.chemical_classification
Reactive oxygen species
lcsh:R5-920
business.industry
Papillomavirus Infections
Human Papillomavirus
General Medicine
medicine.disease
Oxidative Stress
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Cancer research
Redox System
Female
medicine.symptom
business
lcsh:Medicine (General)
Reactive Oxygen Species
Oxidative stress
Subjects
Details
- ISSN :
- 19805322 and 18075932
- Volume :
- 73
- Issue :
- suppl 1
- Database :
- OpenAIRE
- Journal :
- Clinics (Sao Paulo, Brazil)
- Accession number :
- edsair.doi.dedup.....49187c2f17e0b4ffe32ccc230baa00dd