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Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo

Authors :
Sarin, Jaakko K
Te Moller, Nikae C R
Mancini, Irina A D
Brommer, Harold
Visser, Jetze
Malda, Jos
van Weeren, P René
Afara, Isaac O
Töyräs, Juha
LS Equine Muscoskeletal Biology
dES RMSC
dES AVR
LS Heelkunde
Sub General Pharmaceutics
Dep Gezondheidszorg Paard
Geneeskunde van gezelschapsdieren
LS Equine Muscoskeletal Biology
dES RMSC
dES AVR
LS Heelkunde
Sub General Pharmaceutics
Dep Gezondheidszorg Paard
Geneeskunde van gezelschapsdieren
Source :
Scientific Reports, Scientific Reports, 8(1). Nature Publishing Group, Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018), Scientific Reports, 8(1). NLM (Medline)
Publication Year :
2018

Abstract

Arthroscopic assessment of articular tissues is highly subjective and poorly reproducible. To ensure optimal patient care, quantitative techniques (e.g., near infrared spectroscopy (NIRS)) could substantially enhance arthroscopic diagnosis of initial signs of post-traumatic osteoarthritis (PTOA). Here, we demonstrate, for the first time, the potential of arthroscopic NIRS to simultaneously monitor progressive degeneration of cartilage and subchondral bone in vivo in Shetland ponies undergoing different experimental cartilage repair procedures. Osteochondral tissues adjacent to the repair sites were evaluated using an arthroscopic NIRS probe and significant (p ρ = 0.63–0.87, NMRSE = 8.5–17.2%, RPIQ = 1.93–3.03) estimation of articular cartilage biomechanical properties, subchondral bone plate thickness and bone mineral density (BMD), and subchondral trabecular bone thickness, bone volume fraction (BV), BMD, and structure model index (SMI) from in vitro spectral data. The trained ANNs also reliably predicted the properties of an independent in vitro test group (ρ = 0.54–0.91, NMRSE = 5.9–17.6%, RPIQ = 1.68–3.36). However, predictions based on arthroscopic NIR spectra were less reliable (ρ = 0.27–0.74, NMRSE = 14.5–24.0%, RPIQ = 1.35–1.70), possibly due to errors introduced during arthroscopic spectral acquisition. Adaptation of NIRS could address the limitations of conventional arthroscopy through quantitative assessment of lesion severity and extent, thereby enhancing detection of initial signs of PTOA. This would be of high clinical significance, for example, when conducting orthopaedic repair surgeries.

Details

Language :
English
ISSN :
20452322
Volume :
8
Issue :
1
Database :
OpenAIRE
Journal :
Scientific Reports
Accession number :
edsair.doi.dedup.....49161df67407d1f449f03432cc364a67
Full Text :
https://doi.org/10.1038/s41598-018-31670-5