Back to Search
Start Over
Arthroscopic near infrared spectroscopy enables simultaneous quantitative evaluation of articular cartilage and subchondral bone in vivo
- Source :
- Scientific Reports, Scientific Reports, 8(1). Nature Publishing Group, Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018), Scientific Reports, 8(1). NLM (Medline)
- Publication Year :
- 2018
-
Abstract
- Arthroscopic assessment of articular tissues is highly subjective and poorly reproducible. To ensure optimal patient care, quantitative techniques (e.g., near infrared spectroscopy (NIRS)) could substantially enhance arthroscopic diagnosis of initial signs of post-traumatic osteoarthritis (PTOA). Here, we demonstrate, for the first time, the potential of arthroscopic NIRS to simultaneously monitor progressive degeneration of cartilage and subchondral bone in vivo in Shetland ponies undergoing different experimental cartilage repair procedures. Osteochondral tissues adjacent to the repair sites were evaluated using an arthroscopic NIRS probe and significant (p ρ = 0.63–0.87, NMRSE = 8.5–17.2%, RPIQ = 1.93–3.03) estimation of articular cartilage biomechanical properties, subchondral bone plate thickness and bone mineral density (BMD), and subchondral trabecular bone thickness, bone volume fraction (BV), BMD, and structure model index (SMI) from in vitro spectral data. The trained ANNs also reliably predicted the properties of an independent in vitro test group (ρ = 0.54–0.91, NMRSE = 5.9–17.6%, RPIQ = 1.68–3.36). However, predictions based on arthroscopic NIR spectra were less reliable (ρ = 0.27–0.74, NMRSE = 14.5–24.0%, RPIQ = 1.35–1.70), possibly due to errors introduced during arthroscopic spectral acquisition. Adaptation of NIRS could address the limitations of conventional arthroscopy through quantitative assessment of lesion severity and extent, thereby enhancing detection of initial signs of PTOA. This would be of high clinical significance, for example, when conducting orthopaedic repair surgeries.
- Subjects :
- Cartilage, Articular
0301 basic medicine
Bone density
0206 medical engineering
lcsh:Medicine
02 engineering and technology
Osteoarthritis
Article
Arthroscopy
03 medical and health sciences
Bone Density
In vivo
Animals
Osteochondrosis
Medicine
Clinical significance
Horses
lcsh:Science
General
Bone mineral
Spectroscopy, Near-Infrared
Multidisciplinary
medicine.diagnostic_test
business.industry
Cartilage
lcsh:R
medicine.disease
020601 biomedical engineering
030104 developmental biology
medicine.anatomical_structure
Subchondral bone
Cancellous Bone
lcsh:Q
Neural Networks, Computer
business
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....49161df67407d1f449f03432cc364a67
- Full Text :
- https://doi.org/10.1038/s41598-018-31670-5