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Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment
- Source :
- Psychological Medicine, 43, 911-20, Psychological Medicine, 2012, 1-10, Psychological Medicine, 43, 5, pp. 911-20, Psychological Medicine, 43(5), 911-920. Cambridge University Press, Psychological Medicine, 2012, 7, pp. 1-10, Ramakers, I H G B, Verhey, F R J, Scheltens, P, Hampel, H, Soininen, H, Aalten, P, Rikkert, M O, Verbeek, M M, Spiru, L, Blennow, K, Trojanowski, J Q, Shaw, L M & Visser, P J 2013, ' Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment ', Psychological Medicine, vol. 43, no. 5, pp. 911-920 . https://doi.org/10.1017/S0033291712001870
- Publication Year :
- 2013
- Publisher :
- Cambridge University Press, 2013.
-
Abstract
- BackgroundAnxiety, apathy and depression are common in subjects with mild cognitive impairment (MCI) and may herald Alzheimer's disease (AD). We investigated whether these symptoms correlated with cerebrospinal fluid (CSF) markers for AD in subjects with MCI.MethodSubjects with MCI (n=268) were selected from the ‘Development of screening guidelines and criteria for pre-dementia Alzheimer's disease’ (DESCRIPA) and Alzheimer's Disease Neuroimaging Initiative (ADNI) studies. We measured amyloid β(1-42)protein (Aβ42) and total tau (t-tau) in CSF. Neuropsychiatric symptoms were measured with the Neuropsychiatric Inventory.ResultsDepressive symptoms were reported by 55 subjects (21%), anxiety by 35 subjects (13%) and apathy by 49 subjects (18%). The presence of anxiety was associated with abnormal CSF Aβ42 [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.6–3.3] and t-tau (OR 2.6, 95% CI 1.9–3.6) concentrations and with the combination of abnormal concentrations of both Aβ42 and t-tau (OR 3.1, 95% CI 2.0–4.7). The presence of agitation and irritability was associated with abnormal concentrations of Aβ42 (agitation: OR 1.6, 95% CI 1.1–2.3; irritability: OR 2.2, 95% CI 1.5–3.3). Symptoms of depression and apathy were not related to any of the CSF markers.ConclusionsIn subjects with MCI, symptoms of anxiety, agitation and irritability may reflect underlying AD pathology, whereas symptoms of depression and apathy do not.
- Subjects :
- Male
medicine.medical_specialty
DCN MP - Plasticity and memory
Enzyme-Linked Immunosorbent Assay
tau Proteins
apathy
Disease
Neuropsychological Tests
Irritability
Article
cerebrospinal fluid
Cohort Studies
Cerebrospinal fluid
mild cognitive impairment
Alzheimer Disease
Internal medicine
Alzheimer Centre [DCN PAC - Perception action and control NCEBP 11]
mental disorders
Confidence Intervals
Odds Ratio
medicine
Humans
Cognitive Dysfunction
Apathy
Alzheimer Centre [NCEBP 11]
Psychiatry
DCN NN - Brain networks and neuronal communication
Applied Psychology
Depression (differential diagnoses)
Aged
Amyloid beta-Peptides
biomarkers
Odds ratio
Alzheimer's disease
medicine.disease
anxiety
Irritable Mood
Psychiatry and Mental health
depression
Anxiety
Female
neuropsychiatric symptoms
medicine.symptom
Psychology
Subjects
Details
- Language :
- English
- ISSN :
- 14698978 and 00332917
- Volume :
- 43
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Psychological Medicine
- Accession number :
- edsair.doi.dedup.....48fb79047e152f3e216f94ddffcb5f38