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Expressional analysis of immune-related miRNAs in breast milk
- Source :
- Genetics and molecular research : GMR. 14(3)
- Publication Year :
- 2015
-
Abstract
- Immune-related miRNAs in breast milk are extracellular miRNAs that are related to immune organ development and regulation of the immune function in infants and young animals. The goal of this study was to compare the expression levels of five immune-related miRNAs in breast milk in black goats, humans, and dairy cattle. The miRNAs from milk were extracted and the expression levels were assessed using quantitive RT-PCR methods. MiR-146, miR-155, miR-181a, miR-223, and miR-150 were all detected in Dazu black goat milk, and these miRNAs were significantly more highly expressed in colostrum than in mature milk of goats (P < 0.01), except for miR-150. Further, all five miRNAs were expressed in human colostrum, but patterns differed from those in goats: miR-146 and miR-155 were highly expressed (P < 0.01) in human colostrum, whereas miR-223 was abundant in goat colostrum (P < 0.01). In addition, five miRNAs were significantly higher in bovine mature milk than in goat milk (P < 0.01). Taken together, these results confirm that immune-related miRNAs are rich in breast milk with different expression levels depending on the lactation phase and species.
- Subjects :
- Breast milk
Biology
Andrology
fluids and secretions
Immune system
Lactation
microRNA
Genetics
Extracellular
medicine
Animals
Humans
Molecular Biology
Dairy cattle
Milk, Human
Colostrum
Gene Expression Profiling
Goats
food and beverages
General Medicine
Gene expression profiling
MicroRNAs
medicine.anatomical_structure
Milk
Cattle
Female
Subjects
Details
- ISSN :
- 16765680
- Volume :
- 14
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Genetics and molecular research : GMR
- Accession number :
- edsair.doi.dedup.....48fad3c937c1a4282ee5523c8c9455b6