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Direct Genetic Analysis of Single Disseminated Cancer Cells for Prediction of Outcome and Therapy Selection in Esophageal Cancer
- Source :
- Cancer Cell. 13:441-453
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- SummaryThe increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression. To address this problem, we studied the precursor cells of metastases directly for the identification of prognostic and therapeutic markers and prospectively analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients. Whole-genome screening revealed that primary tumors and lymphatically and hematogenously disseminated cancer cells diverged for most genetic aberrations. However, we identified chromosome 17q12–21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites. Survival analysis demonstrated that HER2 gain in a single disseminated tumor cell but not in primary tumors conferred high risk for early death.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Esophageal Neoplasms
Bone Neoplasms
CELLCYCLE
Predictive Value of Tests
Internal medicine
Precursor cell
Humans
Medicine
Neoplasm Metastasis
Survival analysis
Neoplasm Staging
Disseminated Tumor Cell
Genome, Human
business.industry
Chromosome Mapping
Cancer
Cell Biology
Genes, erbB-2
Cell cycle
Esophageal cancer
Prognosis
medicine.disease
Treatment Outcome
medicine.anatomical_structure
Lymphatic Metastasis
Bone marrow
Lymph
business
Chromosomes, Human, Pair 17
Subjects
Details
- ISSN :
- 15356108
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cancer Cell
- Accession number :
- edsair.doi.dedup.....48f8ecf07635568fc12e7c4f2fdfc2b0