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Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin
- Source :
- eLife, eLife, Vol 6 (2017)
- Publication Year :
- 2017
- Publisher :
- eLife Sciences Publications, 2017.
-
Abstract
- In the arcuate nucleus of the hypothalamus (ARH) satiety signaling (anorexigenic) pro-opiomelanocortin (POMC)-expressing and hunger signaling (orexigenic) agouti-related peptide (AgRP)-expressing neurons are key components of the neuronal circuits that control food intake and energy homeostasis. Here, we assessed whether the catecholamine noradrenalin directly modulates the activity of these neurons in mice. Perforated patch clamp recordings showed that noradrenalin changes the activity of these functionally antagonistic neurons in opposite ways, increasing the activity of the orexigenic NPY/AgRP neurons and decreasing the activity of the anorexigenic POMC neurons. Cell type-specific transcriptomics and pharmacological experiments revealed that the opposing effect on these neurons is mediated by the activation of excitatory α1A - and β- adrenergic receptors in NPY/AgRP neurons, while POMC neurons are inhibited via α2A – adrenergic receptors. Thus, the coordinated differential modulation of the key hypothalamic neurons in control of energy homeostasis assigns noradrenalin an important role to promote feeding. DOI: http://dx.doi.org/10.7554/eLife.25770.001
- Subjects :
- 0301 basic medicine
Patch-Clamp Techniques
Pro-Opiomelanocortin
Mouse
POMC-neuron
Energy homeostasis
Mice
Norepinephrine
0302 clinical medicine
Neuromodulation
Agouti-Related Protein
Biology (General)
Neurons
Chemistry
General Neuroscience
digestive, oral, and skin physiology
General Medicine
medicine.anatomical_structure
Hypothalamus
neuromodulation
Medicine
Technology Platforms
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Research Article
medicine.medical_specialty
Adrenergic receptor
QH301-705.5
noradrenalin
Science
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Arcuate nucleus
Orexigenic
Internal medicine
medicine
Animals
Patch clamp
AgRP-neuron
General Immunology and Microbiology
Gene Expression Profiling
Arcuate Nucleus of Hypothalamus
030104 developmental biology
Endocrinology
nervous system
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- eLife, eLife, Vol 6 (2017)
- Accession number :
- edsair.doi.dedup.....48f81dc73e1d51c12d70681edfe9be6c