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Maternal Quercetin Consumption during Pregnancy May Help Regulate Total Cholesterol/HDL-Cholesterol Ratio without Effect on Cholesterol Levels in Male Progeny Consuming High-Fat Diet
- Source :
- Nutrients, Nutrients, Vol 13, Iss 1242, p 1242 (2021), Volume 13, Issue 4
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Quercetin has been shown to have anti-obesity effects, but it is unknown whether these effects can be transmitted from mothers to their progeny. In this study, we investigated whether maternal quercetin consumption during pregnancy has a protective effect on high-fat diet–induced hyper lipid levels and overweight in progeny. Female mice consumed a control diet or a diet containing 1.0% quercetin during breeding. The male progeny were then divided into four groups that were (1) sacrificed at postnatal day 3<br />(2) born to dams fed the control diet and also fed the control diet (C-C), (3) born to dams fed the control diet and then fed a 30% high-fat diet (C-HF), or (4) born to dams fed the Q-diet and then fed the HF diet (Q-HF). Maternal consumption of quercetin did not affect body weight or blood lipid parameters in either dams or neonates at postnatal day 3. After 13 weeks, the Q-HF group exhibited greater body and liver weights, and higher blood cholesterol levels than the C-HF group. However, the total cholesterol/ high density lipoprotein (HDL)-cholesterol ratios in the Q-HF and C-C groups remained similar. In conclusion, maternal quercetin consumption does not appear to protect the next generation from high-fat diet–induced hyper cholesterol level in the blood and liver, and consequently overweight, but may help regulate the total cholesterol/HDL-cholesterol ratio.
- Subjects :
- Male
medicine.medical_specialty
mice
Blood lipids
lcsh:TX341-641
Overweight
Biology
progeny
Diet, High-Fat
Article
chemistry.chemical_compound
High-density lipoprotein
total cholesterol/HDL-cholesterol ratio
Pregnancy
Internal medicine
Total cholesterol
high-fat diet–induced obesity
medicine
Animals
heterocyclic compounds
Triglycerides
Mice, Inbred ICR
Nutrition and Dietetics
Cholesterol
Body Weight
Cholesterol, HDL
Feeding Behavior
Organ Size
medicine.disease
Hormones
Endocrinology
Animals, Newborn
Liver
chemistry
HDL/cholesterol ratio
Female
Quercetin
medicine.symptom
lcsh:Nutrition. Foods and food supply
Food Science
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....48eb0982165d74701cab88bdc6d38038