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Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay
- Source :
- Virology, Virology, Elsevier, 2019, 526, pp.105-116. ⟨10.1016/j.virol.2018.10.013⟩, Virology, 2019, 526, pp.105-116. ⟨10.1016/j.virol.2018.10.013⟩
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- International audience; Equid alpha-herpesviruses (EHV) are responsible for different diseases in equine population. EHV-1 causes respiratory diseases, abortions and nervous disorders, EHV-4 causes respiratory diseases and sporadic abortion, while EHV-3 is responsible of equine coital exanthema. In view of the lack of efficacy of vaccines against EHV-1 and EHV-4 and in the absence of vaccines against EHV-3, the use of antiviral treatment is of great interest. In this study, we documented the interest of the Real-Time Cell Analysis (RTCA) technology to monitor the cytopathic effects induced by these viruses on equine dermal cells, and established the efficacy of this method to evaluate the antiviral effect of aciclovir (ACV) and ganciclovir (GCV). In addition, the RTCA technology has also been found appropriate for the high-throughput screening of small molecules against EHV, allowing the identification of spironolactone as a novel antiviral against EHV.
- Subjects :
- Ganciclovir
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Population
Alpha (ethology)
Cell analysis
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Spironolactone
Biology
Antiviral Agents
Equid herpesviruses
NERVOUS DISORDERS
Cell Line
Real-time cell analysis
03 medical and health sciences
Cytopathogenic Effect, Viral
xCELLigence
Virology
Electric Impedance
medicine
Lack of efficacy
Animals
Horses
Aciclovir
Antiviral
education
030304 developmental biology
0303 health sciences
education.field_of_study
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
Cellular Assay
030302 biochemistry & molecular biology
Impedance
Herpesviridae Infections
High-Throughput Screening Assays
3. Good health
Screening
Herpesvirus 3, Equid
Herpesvirus 4, Equid
Herpesvirus 1, Equid
medicine.drug
Subjects
Details
- ISSN :
- 00426822 and 10960341
- Volume :
- 526
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....48de2f70ca4c472540b25aa89eb36c72