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Analysis of the prognostic significance of lymph node related characteristics in papillary thyroid carcinoma patients presenting with pre- or intra-operative evidence of cervical lymph node metastases
Analysis of the prognostic significance of lymph node related characteristics in papillary thyroid carcinoma patients presenting with pre- or intra-operative evidence of cervical lymph node metastases
- Source :
- The Journal of laryngology and otology. 128(3)
- Publication Year :
- 2014
-
Abstract
- Objective:To identify the prognostic significance of specific lymph node related characteristics for disease persistence and recurrence in patients with pre- or intra-operative evidence of neck metastases and no other risk factors.Method and resultsSixty-eight patients were identified; 50 per cent had persistent or recurrent disease. All underwent the same treatment strategy. There were no statistically significant differences in any of the patient- or tumour-related parameters when patients with and without persistence or recurrence were compared. Patients with recurrent or persistent disease had significantly larger (>3 cm) metastatic lymph nodes, but there were no differences regarding other lymph node related parameters (i.e. number, extracapsular extension, number of lymph nodes with extracapsular extension, and central vs lateral neck location). On multivariate analysis, however, none of the parameters were predictive of persistent or recurrent disease.Conclusion:In papillary thyroid carcinoma patients with no other risk factors, pre- or intra-operative evidence of cervical metastases was associated with a very high rate of disease persistence or recurrence. Specific lymph node characteristics were not shown to have prognostic significance.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Multivariate analysis
Intra operative
Adolescent
Risk Assessment
Thyroid carcinoma
Risk Factors
Internal medicine
Preoperative Care
Recurrent disease
Medicine
Humans
In patient
Neoplasm Invasiveness
Thyroid Neoplasms
Lymph node
Aged
Neoplasm Staging
Postoperative Care
business.industry
General Medicine
Middle Aged
Prognosis
Carcinoma, Papillary
Persistent Disease
medicine.anatomical_structure
Treatment Outcome
Otorhinolaryngology
Lymphatic Metastasis
Thyroidectomy
Neck Dissection
Female
Lymph
Lymph Nodes
Neoplasm Recurrence, Local
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 17485460 and 00222151
- Volume :
- 128
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of laryngology and otology
- Accession number :
- edsair.doi.dedup.....48d7691364445ef3e6e109c8d5cb3cab