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Pentaglobin® Efficacy in Reducing the Incidence of Sepsis and Transplant-Related Mortality in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Study
- Source :
- Journal of Clinical Medicine, Volume 9, Issue 5, Journal of Clinical Medicine, Vol 9, Iss 1592, p 1592 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The 12-month mortality rate in patients undergoing hematopoietic stem cell transplantation (HSCT) remains high, especially with respect to transplant-related mortality (TRM), which includes mortality due to infection complications through the aplasia phase. The aim of this study was to determine whether the administration of Pentaglobin&reg<br />could decrease TRM by lowering sepsis onset or weakening sepsis through the aplasia phase. One hundred and ninety-nine pediatric patients who had undergone HSCT were enrolled in our retrospective study. The patients were divided into two groups: the Pentaglobin group, which had received Pentaglobin&reg<br />in addition to the standard antibiotic treatment protocol established for the aplasia phase, and the Control group, which received only the standard treatment. As compared to the control group outcome, Pentaglobin&reg<br />led to a significant decrease in the days of temperature increase (p &lt<br />0.001) and a reduced infection-related mortality rate (p = 0.04). In addition, the number of antibiotics used to control infections, and the number of antibiotic therapy changes needed following first-line drug failure, were significantly lowered in the Pentaglobin group as compared to the control group (p &lt<br />0.0001). With respect to the onset of new infections following the primary infection detected, the Pentaglobin group showed a significant reduction for bacterial events, as compared to the control group (p &lt<br />0.03). Pentaglobin&reg<br />use in patients undergoing HSCT seems to produce a significant decrease in infection-associated TRM rate.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Pentaglobin®
lcsh:Medicine
Hematopoietic stem cell transplantation
hematopoietic stem cell transplantation
pediatric patients
aplasia
infection-related mortality rate
Article
Sepsis
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
medicine
business.industry
Standard treatment
Mortality rate
Incidence (epidemiology)
lcsh:R
Retrospective cohort study
General Medicine
Aplasia
Transplant-Related Mortality
medicine.disease
surgical procedures, operative
030220 oncology & carcinogenesis
business
pediatric patient
030215 immunology
Subjects
Details
- ISSN :
- 20770383
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....48d046adbd2db1b5823e8c84aed2431c