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Analysis of cellular signal transduction from an information theoretic approach
- Source :
- Seminars in Cell & Developmental Biology. 51:24-31
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Signal transduction processes the information of various cellular functions, including cell proliferation, differentiation, and death. The information for controlling cell fate is transmitted by concentrations of cellular signaling molecules. However, how much information is transmitted in signaling pathways has thus far not been investigated. Shannon's information theory paves the way to quantitatively analyze information transmission in signaling pathways. The theory has recently been applied to signal transduction, and mutual information of signal transduction has been determined to be a measure of information transmission. We review this work and provide an overview of how signal transduction transmits informational input and exerts biological output.
- Subjects :
- 0301 basic medicine
Cell signaling
Entropy
Channel-associated signaling
Information Theory
Cell fate determination
Biology
Bioinformatics
Information theory
03 medical and health sciences
0302 clinical medicine
Animals
Humans
Information transmission
Uncertainty
Computational Biology
Cell Biology
Mutual information
Cellular signal transduction
030104 developmental biology
Signal transduction
Neuroscience
Algorithms
030217 neurology & neurosurgery
Signal Transduction
Developmental Biology
Subjects
Details
- ISSN :
- 10849521
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Seminars in Cell & Developmental Biology
- Accession number :
- edsair.doi.dedup.....48cf7ecf6e33e3273cbbd7b5b263bb8d