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Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort:discrepancies with local readers and impact on the performance of the ASAS criteria

Authors :
Maksymowych, Walter P.
Pedersen, Susanne Juhl
Weber, Ulrich
Baraliakos, Xenofon
MacHado, Pedro M.
Eshed, Iris
De Hooge, Manouk
Sieper, Joachim
Wichuk, Stephanie
Rudwaleit, Martin
Van Der Heijde, Désirée
Landewé, Robert B.M.
Poddubnyy, Denis
Ostergaard, Mikkel
Lambert, Robert G.W.
Clinical Immunology and Rheumatology
AII - Inflammatory diseases
Source :
Maksymowych, W P, Pedersen, S J, Weber, U, Baraliakos, X, Machado, P M, Eshed, I, de Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, van der Heijde, D, Landewé, R B M, Poddubnyy, D, Ostergaard, M & Lambert, R G W 2020, ' Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort : discrepancies with local readers and impact on the performance of the ASAS criteria ', Annals of the rheumatic diseases, vol. 79, no. 7, pp. 935-942 . https://doi.org/10.1136/annrheumdis-2020-217232, Annals of the rheumatic diseases, 79(7), 935-942. BMJ Publishing Group, Annals of the Rheumatic Diseases, 79(7), 935-942. BMJ PUBLISHING GROUP, Maksymowych, W P, Pedersen, S J, Weber, U, Weber, U, Baraliakos, X, MacHado, P M, MacHado, P M, Eshed, I, De Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, Van Der Heijde, D, Van Der Heijde, D, Landewé, R B M, Landewé, R B M, Poddubnyy, D, Ostergaard, M & Lambert, R G W 2020, ' Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort : Discrepancies with local readers and impact on the performance of the ASAS criteria ', Annals of the Rheumatic Diseases, vol. 79, no. 7, pp. 935-942 . https://doi.org/10.1136/annrheumdis-2020-217232
Publication Year :
2020

Abstract

ObjectivesThe Assessment of SpondyloArthritis international Society (ASAS) MRI working group conducted a multireader exercise on MRI scans from the ASAS classification cohort to assess the spectrum and evolution of lesions in the sacroiliac joint and impact of discrepancies with local readers on numbers of patients classified as axial spondyloarthritis (axSpA).MethodsSeven readers assessed baseline scans from 278 cases and 8 readers assessed baseline and follow-up scans from 107 cases. Agreement for detection of MRI lesions between central and local readers was assessed descriptively and by the kappa statistic. We calculated the number of patients classified as axSpA by the ASAS criteria after replacing local detection of active lesions by central readers and replacing local reader radiographic sacroiliitis by central reader structural lesions on MRI.ResultsStructural lesions, especially erosions, were as frequent as active lesions (≈40%), the majority of patients having both types of lesions. The ASAS definitions for active MRI lesion typical of axSpA and erosion were comparatively discriminatory between axSpA and non-axSpA. Local reader overcall for active MRI lesions was about 30% but this had a minor impact on the number of patients (6.4%) classified as axSpA. Substitution of radiography with MRI structural lesions also had little impact on classification status (1.4%).ConclusionDespite substantial discrepancy between central and local readers in interpretation of both types of MRI lesion, this had a minor impact on the numbers of patients classified as axSpA supporting the robustness of the ASAS criteria for differences in assessment of imaging.

Details

Language :
English
ISSN :
00034967
Database :
OpenAIRE
Journal :
Maksymowych, W P, Pedersen, S J, Weber, U, Baraliakos, X, Machado, P M, Eshed, I, de Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, van der Heijde, D, Landewé, R B M, Poddubnyy, D, Ostergaard, M & Lambert, R G W 2020, ' Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort : discrepancies with local readers and impact on the performance of the ASAS criteria ', Annals of the rheumatic diseases, vol. 79, no. 7, pp. 935-942 . https://doi.org/10.1136/annrheumdis-2020-217232, Annals of the rheumatic diseases, 79(7), 935-942. BMJ Publishing Group, Annals of the Rheumatic Diseases, 79(7), 935-942. BMJ PUBLISHING GROUP, Maksymowych, W P, Pedersen, S J, Weber, U, Weber, U, Baraliakos, X, MacHado, P M, MacHado, P M, Eshed, I, De Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, Van Der Heijde, D, Van Der Heijde, D, Landewé, R B M, Landewé, R B M, Poddubnyy, D, Ostergaard, M & Lambert, R G W 2020, ' Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort : Discrepancies with local readers and impact on the performance of the ASAS criteria ', Annals of the Rheumatic Diseases, vol. 79, no. 7, pp. 935-942 . https://doi.org/10.1136/annrheumdis-2020-217232
Accession number :
edsair.doi.dedup.....48cc9b55b8a5c5be02ea1690a21bb61d