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Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort:discrepancies with local readers and impact on the performance of the ASAS criteria
- Source :
- Maksymowych, W P, Pedersen, S J, Weber, U, Baraliakos, X, Machado, P M, Eshed, I, de Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, van der Heijde, D, Landewé, R B M, Poddubnyy, D, Ostergaard, M & Lambert, R G W 2020, ' Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort : discrepancies with local readers and impact on the performance of the ASAS criteria ', Annals of the rheumatic diseases, vol. 79, no. 7, pp. 935-942 . https://doi.org/10.1136/annrheumdis-2020-217232, Annals of the rheumatic diseases, 79(7), 935-942. BMJ Publishing Group, Annals of the Rheumatic Diseases, 79(7), 935-942. BMJ PUBLISHING GROUP, Maksymowych, W P, Pedersen, S J, Weber, U, Weber, U, Baraliakos, X, MacHado, P M, MacHado, P M, Eshed, I, De Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, Van Der Heijde, D, Van Der Heijde, D, Landewé, R B M, Landewé, R B M, Poddubnyy, D, Ostergaard, M & Lambert, R G W 2020, ' Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort : Discrepancies with local readers and impact on the performance of the ASAS criteria ', Annals of the Rheumatic Diseases, vol. 79, no. 7, pp. 935-942 . https://doi.org/10.1136/annrheumdis-2020-217232
- Publication Year :
- 2020
-
Abstract
- ObjectivesThe Assessment of SpondyloArthritis international Society (ASAS) MRI working group conducted a multireader exercise on MRI scans from the ASAS classification cohort to assess the spectrum and evolution of lesions in the sacroiliac joint and impact of discrepancies with local readers on numbers of patients classified as axial spondyloarthritis (axSpA).MethodsSeven readers assessed baseline scans from 278 cases and 8 readers assessed baseline and follow-up scans from 107 cases. Agreement for detection of MRI lesions between central and local readers was assessed descriptively and by the kappa statistic. We calculated the number of patients classified as axSpA by the ASAS criteria after replacing local detection of active lesions by central readers and replacing local reader radiographic sacroiliitis by central reader structural lesions on MRI.ResultsStructural lesions, especially erosions, were as frequent as active lesions (≈40%), the majority of patients having both types of lesions. The ASAS definitions for active MRI lesion typical of axSpA and erosion were comparatively discriminatory between axSpA and non-axSpA. Local reader overcall for active MRI lesions was about 30% but this had a minor impact on the number of patients (6.4%) classified as axSpA. Substitution of radiography with MRI structural lesions also had little impact on classification status (1.4%).ConclusionDespite substantial discrepancy between central and local readers in interpretation of both types of MRI lesion, this had a minor impact on the numbers of patients classified as axSpA supporting the robustness of the ASAS criteria for differences in assessment of imaging.
- Subjects :
- Adult
Male
medicine.medical_specialty
Radiography
Immunology
General Biochemistry, Genetics and Molecular Biology
Cohort Studies
Diagnosis, Differential
outcomes research
Cohen's kappa
Rheumatology
Spondylarthritis
medicine
Humans
Immunology and Allergy
magnetic resonance imaging
Sacroiliitis
Axial spondyloarthritis
Societies, Medical
Observer Variation
Sacroiliac joint
medicine.diagnostic_test
business.industry
International Agencies
Sacroiliac Joint
Magnetic resonance imaging
Middle Aged
spondyloarthritis
medicine.disease
medicine.anatomical_structure
Cohort
Female
Radiology
business
Subjects
Details
- Language :
- English
- ISSN :
- 00034967
- Database :
- OpenAIRE
- Journal :
- Maksymowych, W P, Pedersen, S J, Weber, U, Baraliakos, X, Machado, P M, Eshed, I, de Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, van der Heijde, D, Landewé, R B M, Poddubnyy, D, Ostergaard, M & Lambert, R G W 2020, ' Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort : discrepancies with local readers and impact on the performance of the ASAS criteria ', Annals of the rheumatic diseases, vol. 79, no. 7, pp. 935-942 . https://doi.org/10.1136/annrheumdis-2020-217232, Annals of the rheumatic diseases, 79(7), 935-942. BMJ Publishing Group, Annals of the Rheumatic Diseases, 79(7), 935-942. BMJ PUBLISHING GROUP, Maksymowych, W P, Pedersen, S J, Weber, U, Weber, U, Baraliakos, X, MacHado, P M, MacHado, P M, Eshed, I, De Hooge, M, Sieper, J, Wichuk, S, Rudwaleit, M, Van Der Heijde, D, Van Der Heijde, D, Landewé, R B M, Landewé, R B M, Poddubnyy, D, Ostergaard, M & Lambert, R G W 2020, ' Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort : Discrepancies with local readers and impact on the performance of the ASAS criteria ', Annals of the Rheumatic Diseases, vol. 79, no. 7, pp. 935-942 . https://doi.org/10.1136/annrheumdis-2020-217232
- Accession number :
- edsair.doi.dedup.....48cc9b55b8a5c5be02ea1690a21bb61d