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Inhibition of Skin Inflammation by Scytonemin, an Ultraviolet Sunscreen Pigment
- Source :
- Marine Drugs; Volume 18; Issue 6; Pages: 300, Marine Drugs, Marine Drugs, Vol 18, Iss 300, p 300 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Scytonemin is a yellow-green ultraviolet sunscreen pigment present in different genera of aquatic and terrestrial blue-green algae, including marine cyanobacteria. In the present study, the anti-inflammatory activities of scytonemin were evaluated in vitro and in vivo. Topical application of scytonemin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear swelling in BALB/c mice. The expression of tumor necrosis factor-a (TNF-a) and inducible nitric oxide synthase (iNOS) was also suppressed by scytonemin treatment in the TPA-treated ear of BALB/c mice. In addition, scytonemin inhibited lipopolysaccharide (LPS)-induced production of TNF-a and nitric oxide (NO) in RAW 264.7 cells, a murine macrophage-like cell line, and the mRNA expressions of TNF-a and iNOS were also suppressed by scytonemin in LPS-stimulated RAW 264.7 cells. Further study demonstrated that LPS-induced NF-kB activity was significantly suppressed by scytonemin treatment in RAW 264.7 cells. Our results also showed that the degradation of IkBa and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. Collectively, these results suggest that scytonemin inhibits skin inflammation by blocking the expression of inflammatory mediators, and the anti-inflammatory effect of scytonemin is mediated, at least in part, by down-regulation of NF-kB activity. Our results also suggest that scytonemin might be used as a multi-function skin care ingredient for UV protection and anti-inflammation.
- Subjects :
- Lipopolysaccharides
Indoles
Lipopolysaccharide
Anti-Inflammatory Agents
Nitric Oxide Synthase Type II
Pharmaceutical Science
Inflammation
tumor necrosis factor-
Scytonemin
Nitric Oxide
01 natural sciences
Article
NF-κB
Nitric oxide
Mice
03 medical and health sciences
chemistry.chemical_compound
NF-KappaB Inhibitor alpha
Phenols
skin inflammation
Drug Discovery
medicine
Animals
NF-kB
lcsh:QH301-705.5
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
030304 developmental biology
Mice, Inbred BALB C
0303 health sciences
biology
Tumor Necrosis Factor-alpha
010405 organic chemistry
NF-kappa B
Molecular biology
In vitro
0104 chemical sciences
Nitric oxide synthase
RAW 264.7 Cells
lcsh:Biology (General)
chemistry
Cell culture
biology.protein
scytonemin
Tetradecanoylphorbol Acetate
Tumor necrosis factor alpha
tumor necrosis factor-α
medicine.symptom
nitric oxide
Sunscreening Agents
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Database :
- OpenAIRE
- Journal :
- Marine Drugs; Volume 18; Issue 6; Pages: 300
- Accession number :
- edsair.doi.dedup.....48bfa3ad92fabdd86944405b21fe64c3
- Full Text :
- https://doi.org/10.3390/md18060300