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Immune Thrombocytopenia Due to a Drug Metabolite

Authors :
Eric V. Eisner
Nasrollah T. Shahidi
Source :
New England Journal of Medicine. 287:376-381
Publication Year :
1972
Publisher :
Massachusetts Medical Society, 1972.

Abstract

A patient who developed thrombocytopenia while taking analgesics was found to have circulating antibody to a metabolic product of N-acetyl-p-aminophenol (NAPA), but not to the drug itself. The antibody reacted in vitro with an antigen present in the blood of a normal volunteer who had ingested NAPA. The antigenic material was purified from the urine of this volunteer and shown to be the sulfate conjugate of the drug. These findings demonstrate that a drug metabolite may be antigenically active in drug-induced thrombocytopenia when the drug itself is immunologically inert, representing a form of drug-induced thrombocytopenia.

Details

ISSN :
15334406 and 00284793
Volume :
287
Database :
OpenAIRE
Journal :
New England Journal of Medicine
Accession number :
edsair.doi.dedup.....48bdd81c74594e72fccb60ba24d290c4