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Immune Thrombocytopenia Due to a Drug Metabolite
- Source :
- New England Journal of Medicine. 287:376-381
- Publication Year :
- 1972
- Publisher :
- Massachusetts Medical Society, 1972.
-
Abstract
- A patient who developed thrombocytopenia while taking analgesics was found to have circulating antibody to a metabolic product of N-acetyl-p-aminophenol (NAPA), but not to the drug itself. The antibody reacted in vitro with an antigen present in the blood of a normal volunteer who had ingested NAPA. The antigenic material was purified from the urine of this volunteer and shown to be the sulfate conjugate of the drug. These findings demonstrate that a drug metabolite may be antigenically active in drug-induced thrombocytopenia when the drug itself is immunologically inert, representing a form of drug-induced thrombocytopenia.
- Subjects :
- Adult
Male
Drug
Immunodiffusion
Chromatography, Paper
Lipoproteins
media_common.quotation_subject
Pharmacology
Antigen-Antibody Reactions
Drug Hypersensitivity
Sulfate conjugate
Antigen
Animals
Humans
Medicine
Electrophoresis, Paper
Antigens
Immunoelectrophoresis
Volunteer
Acetaminophen
media_common
Blood coagulation test
biology
Sulfates
business.industry
Goats
Complement Fixation Tests
General Medicine
Chromatography, Ion Exchange
Thrombocytopenia
In vitro
Immunoglobulin M
Immunoglobulin G
Immunology
Chromatography, Gel
biology.protein
Blood Coagulation Tests
Antibody
business
Subjects
Details
- ISSN :
- 15334406 and 00284793
- Volume :
- 287
- Database :
- OpenAIRE
- Journal :
- New England Journal of Medicine
- Accession number :
- edsair.doi.dedup.....48bdd81c74594e72fccb60ba24d290c4