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Pharmacokinetics of three formulations of vitacoxib in horses
- Source :
- Journal of Veterinary Pharmacology and Therapeutics. 43:364-368
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The pharmacokinetic properties of three formulations of vitacoxib were investigated in horses. To describe plasma concentrations and characterize the pharmacokinetics, 6 healthy adult Chinese Mongolian horses were administered a single dose of 0.1 mg/kg bodyweight intravenous (i.v.), oral paste, or oral tablet vitacoxib in a 3-way, randomized, parallel design. Blood samples were collected prior to and at various times up to 72 hr postadministration. Plasma vitacoxib concentrations were quantified using UPLC-MS/MS, and pharmacokinetic parameters were calculated using noncompartmental analysis. No complications resulting from the vitacoxib administration were noted on subsequent administrations, and all procedures were tolerated well by the horses throughout the study. The elimination half-life (T1/2λz ) was 4.24 ± 1.98 hr (i.v.), 8.77 ± 0.91 hr (oral paste), and 8.12 ± 4.24 hr (oral tablet), respectively. Maximum plasma concentration (Cmax ) was 28.61 ± 9.29 ng/ml (oral paste) and 19.64 ± 9.26 ng/ml (oral tablet), respectively. Area under the concentration-versus-time curve (AUClast ) was 336 ± 229 ng hr/ml (i.v.), 221 ± 94 ng hr/ml (oral paste), and 203 ± 139 ng hr/ml, respectively. The results showed statistically significant differences between the 2 oral vitacoxib groups in Tmax value. T1/2λz (hr), AUClast (ng hr/ml), and MRT (hr) were significantly different between i.v. and oral groups. The longer half-life observed following oral administration was consistent with the flip-flop phenomenon.
- Subjects :
- Male
Cmax
Administration, Oral
Biological Availability
010501 environmental sciences
Oral Paste
01 natural sciences
03 medical and health sciences
Animal science
Pharmacokinetics
Oral administration
Animals
Medicine
Horses
Sulfones
030304 developmental biology
0105 earth and related environmental sciences
Pharmacology
0303 health sciences
Cross-Over Studies
General Veterinary
business.industry
Parallel design
Imidazoles
Horse
Noncompartmental analysis
Area Under Curve
Injections, Intravenous
Plasma concentration
Female
business
Half-Life
Subjects
Details
- ISSN :
- 13652885 and 01407783
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Pharmacology and Therapeutics
- Accession number :
- edsair.doi.dedup.....48b10318b6295d45b3700db37ca73b1b