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Experimental evidence for the involvement of F0/F1 ATPase and subsequent P2Y12 receptor activation in prothymosin alpha-induced protection of retinal ischemic damage
- Source :
- Journal of Pharmacological Sciences, Vol 143, Iss 2, Pp 127-131 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- The inhibition of retinal ischemia-induced damage by post-ischemic prothymosin alpha (ProTα) was not affected in toll-like receptor 4 knockout (TLR4-/-) mice but blocked by the pretreatment with antibody against F0/F1 ATPase α- or β-subunit, novel candidate for ProTα-receptor. In addition to the previous observation of ProTα-induced ATP release from cells, the present study showed a ProTα-induced enhancement of ATP hydrolysis activity of recombinant ATP5A1/5B complex. As the protection of retinal function by post-ischemic ProTα was abolished by anti-P2Y12 antibody, the activation of F0/F1 ATPase and subsequent P2Y12 receptor system may play roles in beneficial actions by post-ischemic ProTα.
- Subjects :
- 0301 basic medicine
Prothymosin alpha
ATPase
Ischemia
Prothymosin Alpha
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
ATP hydrolysis
law
medicine
Receptor
Pharmacology
biology
Chemistry
lcsh:RM1-950
Retinal
medicine.disease
Cell biology
030104 developmental biology
lcsh:Therapeutics. Pharmacology
biology.protein
Recombinant DNA
Molecular Medicine
F0/F1 ATPase and P2Y12 receptor system
Antibody
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 13478613
- Volume :
- 143
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological Sciences
- Accession number :
- edsair.doi.dedup.....48afae115719def15c1c54b3a1928ddf