Polyoma tumorigenesis in mice: evidence for dominant resistance and dominant susceptibility genes of the host

We have determined the tumor responses of nine inbred mouse strains and of two F1 hybrids following inoculation with polyoma virus. The results showed wide variations in the frequencies of mice developing tumors. Correlations with H-2 haplotype were evident. C3H/BiDa mice of H-2 k type were fully susceptible, while C57BL/6 mice of H-2 b type were completely resistant. DBA/2 and BALB/c mice, both H-2 d , were of low susceptibility. Contributions of the major histo-compatibility complex were demonstrated using pairs of H-2 congenic mice. Substitution of H-2 k on either a BALB/c or a C57BL/10 background resulted in an increase in the frequencies and kinds of tumors induced. Susceptibilities of BALB and C57BL mice bearing the H-2 k haplotype were still well below those of C3H/BiDa mice, however. Crosses of C3H/BiDa with BALB/c or BALB.K (H-2 k ) produced Fls that were of moderate and full susceptibility, respectively. These results indicate two distinct classes of host genes, one at the H-2 locus where different alleles confer varying degrees of resistance and the other a dominant susceptibility gene(s) carried in C3H/BiDa mice.