Back to Search
Start Over
Assessment of tumor margins in head and neck cancer using a 3D-navigation system based on PET/CT image-fusion - A pilot study
- Source :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. 46(4)
- Publication Year :
- 2017
-
Abstract
- Objectives Determination of tumor margins in patients with squamous cell carcinoma of the head and neck (SCCHN) is mostly based on preoperative magnetic resonance imaging (MRI) or computed tomography scans (CT). Local recurrence of disease is often correlated with the presence of positive resection margins after surgical treatment. Positron emission tomography/computed tomography (PET/CT) imaging plays a crucial role in the assessment of patients with SCCHN. The purpose of this study was to determine whether PET/CT could predict tumor extension. Methods In 12 patients who underwent surgical treatment of primary SCCHN (Stage III-IV) F18-FDG PET/CT image-fusion was performed on a 3D navigation-system based workstation. Image-guided needle biopsies were obtained from four different, color-coded metabolic areas within the tumor. The histopathological findings were correlated with findings on corresponding PET/CT scans. Results 81.3% of biopsies from the central area were positive. Specimens taken from the outer metabolic zone were positive in 66.7% of the patients. The highest incidence of positive biopsies was found in the zone adjacent to the outermost area. There was a statistically significant difference in positive tumor histopathology when comparing the various metabolic zones (p = 0.03). Conclusion Exact determination of tumor is an important research topic, although results remain controversial. The results of this study suggest that in some cases PET scans may overestimate tumor extension.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pilot Projects
Radiography, Interventional
03 medical and health sciences
0302 clinical medicine
Imaging, Three-Dimensional
Positron Emission Tomography Computed Tomography
medicine
Humans
Prospective Studies
Stage (cooking)
Aged
Image fusion
PET-CT
medicine.diagnostic_test
business.industry
Significant difference
Head and neck cancer
Biopsy, Needle
Margins of Excision
Magnetic resonance imaging
030206 dentistry
Middle Aged
medicine.disease
Otorhinolaryngology
Positron emission tomography
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Surgery
Histopathology
Female
Radiology
Oral Surgery
business
Subjects
Details
- ISSN :
- 18784119
- Volume :
- 46
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
- Accession number :
- edsair.doi.dedup.....48a6d3b47ccabe48c13aed10d6d5f585