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Significant association between systolic and diastolic blood pressure elevations and periodic limb movements in patients with idiopathic restless legs syndrome
- Source :
- Sleep Medicine. 17:109-120
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Objective A new and unique methodology was developed to evaluate the association between periodic limb movements (PLMs) and nocturnal blood pressure (BP) excursions in patients with restless legs syndrome (RLS). Methods All data were collected at baseline of the ENCORE (Effects of Neupro on Cardiovascular Observations in Patients with Restless Legs Syndrome) study, a placebo-controlled polysomnographic study of rotigotine in patients with idiopathic RLS. Continuous beat-by-beat BP and heart rate assessments were performed during a full night of polysomnography. All BP elevations occurring with and without PLMs were systematically identified and analyzed. Results Patients ( n = 89) had a mean total of 508.9 ± 405.7 PLMs, 788.4 ± 261.9 systolic BP elevations, and 349.7 ± 242.9 diastolic BP elevations during the night. Higher time-adjusted frequencies of systolic BP elevations [mean difference (95% confidence interval, CI): 543.0 (487.2, I); p 0.0001] and diastolic BP elevations (205.8 (169.3, I); p 0.0001) were observed with PLMs than without PLMs. A peak in the frequency of PLM onset coincided with BP elevation onset. Conclusion Our methodology allowed the first evaluation of the total number of nocturnal PLM-associated BP elevations occurring in patients with RLS. Our data clearly indicate an interdependence between BP elevations and PLMs, and they have clinical relevance as BP variability is a potential cardiovascular risk factor.
- Subjects :
- Adult
Male
medicine.medical_specialty
Systole
Polysomnography
Diastole
Blood Pressure
Nocturnal Myoclonus Syndrome
Young Adult
03 medical and health sciences
0302 clinical medicine
Heart Rate
Risk Factors
Restless Legs Syndrome
Internal medicine
Heart rate
medicine
Humans
Restless legs syndrome
Aged
medicine.diagnostic_test
business.industry
Rotigotine
General Medicine
Middle Aged
medicine.disease
3. Good health
Surgery
Blood pressure
030228 respiratory system
Cardiology
Female
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 13899457
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Sleep Medicine
- Accession number :
- edsair.doi.dedup.....489a74eeb2487e00e93b97eae1e950e4