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The role of the bronchial microvasculature in the airway remodelling in asthma and COPD
- Source :
- Respiratory Research, Vol 11, Iss 1, p 132 (2010), Respiratory Research
- Publication Year :
- 2010
-
Abstract
- In recent years, there has been increased interest in the vascular component of airway remodelling in chronic bronchial inflammation, such as asthma and COPD, and in its role in the progression of disease. In particular, the bronchial mucosa in asthmatics is more vascularised, showing a higher number and dimension of vessels and vascular area. Recently, insight has been obtained regarding the pivotal role of vascular endothelial growth factor (VEGF) in promoting vascular remodelling and angiogenesis. Many studies, conducted on biopsies, induced sputum or BAL, have shown the involvement of VEGF and its receptors in the vascular remodelling processes. Presumably, the vascular component of airway remodelling is a complex multi-step phenomenon involving several mediators. Among the common asthma and COPD medications, only inhaled corticosteroids have demonstrated a real ability to reverse all aspects of vascular remodelling. The aim of this review was to analyze the morphological aspects of the vascular component of airway remodelling and the possible mechanisms involved in asthma and COPD. We also focused on the functional and therapeutic implications of the bronchial microvascular changes in asthma and COPD.
- Subjects :
- Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Angiogenesis
Bronchi
Review
Respiratory Mucosa
Disease
INHALED CORTICOSTEROIDS
OBSTRUCTIVE PULMONARY-DISEASE
Vascular remodelling in the embryo
Pulmonary Disease, Chronic Obstructive
chemistry.chemical_compound
MUCOSAL BLOOD-FLOW
INDUCED PLASMA EXUDATION
medicine
Animals
Humans
Airway Remodelling
Receptor
INDUCED SPUTUM
Asthma
lcsh:RC705-779
COPD
business.industry
lcsh:Diseases of the respiratory system
respiratory system
medicine.disease
respiratory tract diseases
Vascular endothelial growth factor
chemistry
Microvessels
Immunology
ENDOTHELIAL GROWTH-FACTOR
Airway Remodeling
ENDOTHELIAL GROWTH-FACTOR, OBSTRUCTIVE PULMONARY-DISEASE, EXERCISE-INDUCED BRONCHOCONSTRICTION, INDUCED PLASMA EXUDATION, MUCOSAL BLOOD-FLOW, STRUCTURAL-CHANGES, INHALED CORTICOSTEROIDS, INDUCED SPUTUM
EXERCISE-INDUCED BRONCHOCONSTRICTION
business
STRUCTURAL-CHANGES
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Respiratory Research, Vol 11, Iss 1, p 132 (2010), Respiratory Research
- Accession number :
- edsair.doi.dedup.....4898f052275ed2720ae18042f67cb16d