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Oscillatory and intrinsic membrane properties of guinea pig nucleus prepositus hypoglossi neurons in vitro

Oscillatory and intrinsic membrane properties of guinea pig nucleus prepositus hypoglossi neurons in vitro

Authors :
Erwin Idoux
Michel Muhlethaler
L. E. Moore
Mathieu Beraneck
Mauro Serafin
Pierre-Paul Vidal
Patrice Fort
Nicolas Vibert
Neurobiologie des réseaux sensorimoteurs (NRS (U7060))
Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)
Department of Biomedical Engineering [Boston]
Boston University [Boston] (BU)
Laboratoire de Neurobiologie des Réseaux Sensorimoteurs (LNRS)
Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)
Boston University [Boston] ( BU )
Laboratoire de Neurobiologie des Réseaux Sensorimoteurs ( LNRS )
Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris Descartes - Paris 5 ( UPD5 )
Centre de Recherches sur la Cognition et l'Apprentissage ( CeRCA )
Université de Poitiers-Université de Tours-Centre National de la Recherche Scientifique ( CNRS )
Centre médical universitaire de Genève (CMU)
Département de Physiologie, Genève, Suisse
Centre médical universitaire
Centre de recherche en neurosciences de Lyon (CRNL)
Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Team Physiopathologie des Réseaux Neuronaux Responsables du Cycle Veille-Sommeil
Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)
Centre d'étude de la SensoriMotricité (CESEM - UMR 8194)
Université Paris Descartes - Paris 5 (UPD5)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Equipe Pharmacognosie (UMR 8638)
Chimie Organique, Médicinale et Extractive et Toxicologie Expérimentale (COMETE - UMR 8638)
Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Team Physiopathologie des Réseaux Neuronaux Responsables du Cycle Veille-Sommeil (INSERM U1028 - CNRS UMR 5292 - UNIV Lyon 1)
Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)
Neurobiologie des réseaux sensorimoteurs ( NRS (U7060) )
Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS )
Centre de Recherches sur la Cognition et l'Apprentissage (CeRCA)
Université de Poitiers-Université de Tours-Centre National de la Recherche Scientifique (CNRS)
Source :
Journal of Neurophysiology, Journal of Neurophysiology, American Physiological Society, 2006, 96, pp.175, Journal of Neurophysiology, American Physiological Society, 2006, 96 (1), pp.175-96. ⟨10.1152/jn.01355.2005⟩, Journal of Neurophysiology, Vol. 96, No 1 (2006) pp. 175-196, Journal of Neurophysiology, American Physiological Society, 2006, 96 (1), pp.175-96. 〈10.1152/jn.01355.2005〉, Journal of Neurophysiology, American Physiological Society, 2006, 96 (1), pp.175-196. ⟨10.1152/jn.01355.2005⟩
Publication Year :
2006
Publisher :
HAL CCSD, 2006.

Abstract

Numerous models of the oculomotor neuronal integrator located in the prepositus hypoglossi nucleus (PHN) involve both highly tuned recurrent networks and intrinsic neuronal properties; however, there is little experimental evidence for the relative role of these two mechanisms. The experiments reported here show that all PHN neurons (PHNn) show marked phasic behavior, which is highly oscillatory in ∼25% of the population. The behavior of this subset of PHNn, referred to as type D PHNn, is clearly different from that of the medial vestibular nucleus neurons, which transmit the bulk of head velocity-related sensory vestibular inputs without integrating them. We have investigated the firing and biophysical properties of PHNn and developed data-based realistic neuronal models to quantitatively illustrate that their active conductances can produce the oscillatory behavior. Although some individual type D PHNn are able to show some features of mathematical integration, the lack of robustness of this behavior strongly suggests that additional network interactions, likely involving all types of PHNn, are essential for the neuronal integrator. Furthermore, the relationship between the impulse activity and membrane potential of type D PHNn is highly nonlinear and frequency-dependent, even for relatively small-amplitude responses. These results suggest that some of the synaptic input to type D PHNn is likely to evoke oscillatory responses that will be nonlinearly amplified as the spike discharge rate increases. It would appear that the PHNn have specific intrinsic properties that, in conjunction with network interconnections, enhance the persistent neural activity needed for their function.

Subjects

Subjects :
Male
Action Potentials/physiology
Periodicity
MESH: Periodicity
MESH : Electric Stimulation
Physiology
[SDV]Life Sciences [q-bio]
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Membrane Potentials/ physiology
Medial vestibular nucleus
Action Potentials
MESH : Neurons, Afferent
Membrane Potentials
Nucleus prepositus
0302 clinical medicine
Oculomotor Nerve
MESH : Membrane Potentials
MESH : Female
MESH: Animals
MESH: Models, Theoretical
ComputingMilieux_MISCELLANEOUS
MESH: Action Potentials
Motor Neurons
Membrane potential
Vestibular system
Medulla Oblongata
0303 health sciences
education.field_of_study
Chemistry
MESH: Neurons, Afferent
General Neuroscience
MESH: Electric Stimulation
MESH : Medulla Oblongata
medicine.anatomical_structure
Membrane
MESH : Periodicity
[ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
MESH: Vestibular Nuclei
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Female
MESH : Guinea Pigs
MESH: Motor Neurons
Oculomotor Nerve/ physiology
MESH : Motor Neurons
MESH : Oculomotor Nerve
MESH : Male
Guinea Pigs
Models, Neurological
Population
Medulla Oblongata/ physiology
Sensory system
MESH: Guinea Pigs
03 medical and health sciences
MESH : Action Potentials
MESH: Models, Neurological
MESH: Medulla Oblongata
Neurons, Afferent/ physiology
medicine
MESH : Models, Neurological
Animals
MESH: Membrane Potentials
Neurons, Afferent
education
030304 developmental biology
MESH: Oculomotor Nerve
Vestibular Nuclei/physiology
MESH : Models, Theoretical
Vestibular Nuclei
Models, Theoretical
Electric Stimulation
MESH: Male
ddc:616.8
Motor Neurons/physiology
MESH : Animals
MESH : Vestibular Nuclei
MESH: Female
Neuroscience
Nucleus
030217 neurology & neurosurgery

Details

Language :
English
ISSN :
00223077 and 15221598
Database :
OpenAIRE
Journal :
Journal of Neurophysiology, Journal of Neurophysiology, American Physiological Society, 2006, 96, pp.175, Journal of Neurophysiology, American Physiological Society, 2006, 96 (1), pp.175-96. ⟨10.1152/jn.01355.2005⟩, Journal of Neurophysiology, Vol. 96, No 1 (2006) pp. 175-196, Journal of Neurophysiology, American Physiological Society, 2006, 96 (1), pp.175-96. 〈10.1152/jn.01355.2005〉, Journal of Neurophysiology, American Physiological Society, 2006, 96 (1), pp.175-196. ⟨10.1152/jn.01355.2005⟩
Accession number :
edsair.doi.dedup.....489492cd571f96480d306ade6f2b2d50
Full Text :
https://doi.org/10.1152/jn.01355.2005⟩