The Relationship of Thyroid Nodules with Total Serum IgE Level and Metabolic Parameters in Patients with Hashimoto Thyroiditis

Introduction:The literature demonstrates elevated immunoglobulin E (IgE) levels in autoimmune thyroid diseases and their relationship with allergic diseases. The purpose of this study was to describe the relationship between thyroid nodules and total serum IgE levels and metabolic parameters in patients with Hashimoto thyroiditis.Methods:The study included 627 Hashimoto thyroiditis patients [500 (female: 406, male: 94) with and 127 (female: 101, male: 26) without thyroid nodules] and 292 (female: 224, male: 68) healthy control patients. Total serum IgE levels, metabolic parameters, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), total cholesterol, low-density lipoprotein cholesterol, triglyceride, uric acid, free-T4, free-T3, thyroid stimulating hormone, anti-thyroglobulin, anti-thyroid peroxidase, C-reactive protein (CRP) levels, and sedimentation rate were measured in all groups. Moreover, SPSS was used to analyze the results.Results:The mean age, serum IgE levels, mean FBG, HbA1c, and CRP levels of the thyroid nodule group were statistically significantly higher than the non-nodule and control groups (p˂0.05). In all Hashimoto thyroiditis patients, metabolic parameter levels were statistically significantly higher than in control groups (p˂0.05).Conclusion:There is a significant relationship between serum total IgE levels and thyroid nodules. Furthermore, thyroid nodule development appears to be influenced by metabolic and inflammatory abnormalities. These findings confirm the presence of multisystem factors in the development of thyroid nodules.