Back to Search
Start Over
Carotid chemoreceptor denervation does not impair hypoxia-induced thermal downregulation but vitiates recovery from a hypothermic and hypometabolic state in mice
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019), Scientific Reports, 9(1). NLM (Medline), Scientific reports, 9(1):5132. Nature Publishing Group, Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- Induction of hypothermia and consequent hypometabolism by pharmacological downmodulation of the internal thermostat could be protective in various medical situations such as ischemia/reperfusion. Systemic hypoxia is a trigger of thermostat downregulation in some mammals, which is sensed though carotid chemoreceptors (carotid bodies, CBs). Using non-invasive thermographic imaging in mice, we demonstrated that surgical bilateral CB denervation does not hamper hypoxia-induced hypothermia. However, the recovery from a protective and reversible hypothermic state after restoration to normoxic conditions was impaired in CB-resected mice versus control animals. Therefore, the carotid chemoreceptors play an important role in the central regulation of hypoxia-driven hypothermia in mice, but only in the rewarming phase.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Systemic hypoxia
Ischemia
Down-Regulation
lcsh:Medicine
Hypothermia
Article
Mice
03 medical and health sciences
Carotid chemoreceptor
0302 clinical medicine
Downregulation and upregulation
Internal medicine
Thermographic imaging
medicine
Animals
Hypoxia
lcsh:Science
Denervation
Carotid Body
Multidisciplinary
business.industry
lcsh:R
Hypoxia (medical)
medicine.disease
Carotid Arteries
030104 developmental biology
Endocrinology
Female
lcsh:Q
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....488837c6b4183b625eb888d6c601e666