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MRI criteria of subtypes of adenomas and epithelial cysts of the pituitary gland
- Source :
- Neurosurgical review. 43(1)
- Publication Year :
- 2018
-
Abstract
- This study aimed to assess the clinical applicability of MRI criteria for differentiation of pituitary adenomas and cystic pituitary lesions. One hundred ninety-eight consecutive patients with surgical resection of a pituitary adenoma/cystic pituitary lesion were retrospectively analyzed, blinded to clinical data and histopathological diagnosis. Different morphologic criteria were assessed: signal intensity in T2/T1w images, pattern of contrast enhancement, size, super-/infrasellar extension, and invasion of the cavernous sinus. For validation of the criteria, a second independent patient cohort (n = 102) was analyzed for diagnostic accuracy of the criteria. We identified differences between subtypes of pituitary adenomas regarding morphological MRI criteria. Especially, ACTH-producing adenomas and GH-producing adenomas showed partially specific imaging features. Application of our criteria on the second patient cohort (n = 102) did however not significantly improve diagnostic accuracy. Only differentiation between cystic pituitary lesions and adenomas was facilitated using these criteria, but did not reach statistical significance in this cohort (P = 0.352). MRI criteria might facilitate differentiation between pituitary adenomas and cystic pituitary lesions, but not between subtypes of pituitary adenomas. These subtypes show partially specific MR imaging features, however, due to a high variability knowledge of clinical symptoms and laboratory findings remain essential for the correct diagnosis.
- Subjects :
- Adenoma
Adult
Male
Pituitary gland
Pathology
medicine.medical_specialty
Contrast enhancement
Epidermal Cyst
Neuroendocrinology
030218 nuclear medicine & medical imaging
Lesion
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Pituitary adenoma
medicine
Humans
Pituitary Neoplasms
Aged
Retrospective Studies
business.industry
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Cohort
Cavernous sinus
Surgery
Cavernous Sinus
Female
Neurology (clinical)
Neurosurgery
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14372320
- Volume :
- 43
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neurosurgical review
- Accession number :
- edsair.doi.dedup.....4885973e9c6b4b8d12796a1694d3a6e1