Back to Search
Start Over
Assessment of quality of life in adult patients with GH deficiency: KIMS contribution to clinical practice and pharmacoeconomic evaluations
- Source :
- European journal of endocrinology. 161
- Publication Year :
- 2009
-
Abstract
- Quality of life (QoL) has emerged as an important construct that has found numerous applications across healthcare-related fields, ranging from research and clinical evaluation of treatment effects to pharmacoeconomic evaluations and global healthcare policy. Impairment of QoL is one of the key clinical characteristics in adult GHD and has been extensively studied in the Pfizer International Metabolic Database (KIMS). We provide summarized evidence on GH treatment effects for both clinical and health economic applications based on the KIMS data. The primary focus is on those aspects of QoL research that cannot be investigated in the traditional clinical trial setting, such as specific patient subgroups, cross-country comparisons and long-term follow-up. First, the impact of age, gender, disease onset, primary aetiology, extent of hypopituitarism, previous radiotherapy and obesity on QoL before and during long-term GH replacement is discussed. Secondly, the studies on QoL in relation to country-specific normative values are reviewed. Finally, health economic data derived from KIMS including both burden of disease and utility assessment are evaluated. We conclude that the wide spectrum of analyses performed on the KIMS data allows for practical application of the results not only to research and clinical practice but also to health policy and global medical decision making.
- Subjects :
- Gerontology
Adult
Male
medicine.medical_specialty
Databases, Factual
Endocrinology, Diabetes and Metabolism
International Cooperation
MEDLINE
Drug Costs
Hypopituitarism
Endocrinology
Sex Factors
Quality of life
Internal medicine
medicine
Humans
Insulin-Like Growth Factor I
Health policy
Aged
business.industry
Human Growth Hormone
Confounding
Age Factors
Confounding Factors, Epidemiologic
General Medicine
Middle Aged
Clinical trial
Etiology
Quality of Life
Normative
Health Resources
Female
Construct (philosophy)
business
Biomarkers
Subjects
Details
- ISSN :
- 1479683X
- Volume :
- 161
- Database :
- OpenAIRE
- Journal :
- European journal of endocrinology
- Accession number :
- edsair.doi.dedup.....487f406c266baa1d4682af30198be9d9