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Expression of CD109 in human cancer
- Source :
- Oncogene. 23(20)
- Publication Year :
- 2004
-
Abstract
- It was recently reported that the human CD109 gene encodes a glycosyl-phosphatidylinositol-anchored glycoprotein that is a member of the alpha(2)-macroglobulin/C3, C4, C5 family of thioester-containing proteins. In this study, we found that the expression of mouse CD109 gene was upregulated in NIH3T3 cells expressing RET tyrosine kinase with a multiple endocrine neoplasia 2B mutation. Northern blot analysis showed a high level of expression of the CD109 gene only in the testis in normal human and mouse tissues. In addition, its expression was high in some human tumor cell lines, which included squamous cell carcinoma and glioblastoma cell lines, whereas it was undetectable in neuroblastoma and small-cell lung carcinoma cell lines. When CD109 expression was examined in 33 cases of human lung cell carcinomas by quantitative RT-PCR, a significant high expression of CD109 was detected in about half of squamous cell carcinomas examined, but not in adenocarcinoma, large-cell carcinoma and small-cell carcinoma. Similarly, upregulation of CD109 was observed in nine out of 17 esophageal squamous cell carcinomas. Thus, these results suggested that CD109 might be a useful molecular target for the development of new therapeutics for malignant tumors, such as squamous cell carcinoma.
- Subjects :
- Male
Cancer Research
Lung Neoplasms
Esophageal Neoplasms
Cell
Molecular Sequence Data
Biology
medicine.disease_cause
GPI-Linked Proteins
Mice
Antigens, CD
Neoplasms
Gene expression
Testis
Genetics
medicine
Carcinoma
Animals
Humans
Northern blot
Amino Acid Sequence
Lung cancer
Molecular Biology
medicine.disease
Blotting, Northern
Neoplasm Proteins
medicine.anatomical_structure
Epidermoid carcinoma
Organ Specificity
COS Cells
Cancer research
Carcinoma, Squamous Cell
Adenocarcinoma
Carcinogenesis
Sequence Alignment
Subjects
Details
- ISSN :
- 09509232
- Volume :
- 23
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Oncogene
- Accession number :
- edsair.doi.dedup.....487872029d2e97e6f058227879830aec