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Effect of haloperidol on the development of the solid ehrlich tumor in mice
- Source :
- Life Sciences. 60:PL69-PL74
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- We determined the effect of 13 days of treatment with 2.0 mg/kg haloperidol (s.c) on the development of the Ehrlich solid carcinoma, after inoculation of 1.5 x 10(6) Ehrlich ascites tumor cells into the left footpad of mice. The footpad thickness of haloperidol treated animals was significantly smaller than control from day two after tumor inoculation, to the end of the experiment. Histopathological examination showed that haloperidol treated mice apparently presented less necrotic areas within the tumor mass as well as less invasion of subepithelial connective tissue and other adjacent structures. In particular, in comparison with the control group, no nerve bundles were invaded by neoplastic cells in experimental mice. The possible mechanism underlying these results is discussed in light of the specific pharmacological properties of this neuroleptics drug.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Necrosis
Connective tissue
Tumor cells
Histopathological examination
Ehrlich ascites
General Biochemistry, Genetics and Molecular Biology
Mice
medicine
Haloperidol
Animals
Neoplasm Invasiveness
General Pharmacology, Toxicology and Pharmaceutics
Carcinoma, Ehrlich Tumor
Solid Carcinoma
Analysis of Variance
Inoculation
business.industry
General Medicine
medicine.anatomical_structure
medicine.symptom
business
Antipsychotic Agents
medicine.drug
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....48771a120664354b8b3f7c0fd9b18600