A cross-linked copolypeptide with increased affinity for cations

Authors :: Yung D. Kim
Irving M. Klotz
Source :: Biopolymers. 11:431-441
Publication Year :: 1972
Publisher :: Wiley, 1972.
Abstract: The copolymer poly Glu42Lys28Ala30 was crosslinked by S–S bridges by reaction with butyrothiolactone followed by air oxidation of the mercaptan covalent adduct. The modified copolypeptide was more compact hydrodynamically, more resistant to the structurally disruptive effects of urea, and able to bind dye cations with much increased avidity.