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Management of Hyperglycaemia by Ethyl Acetate Extract of Balanites aegyptiaca (Desert Date)
- Source :
- Molecules, Vol 20, Iss 8, Pp 14425-14434 (2015), Molecules, Volume 20, Issue 8, Pages 14425-14434
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- Reactive oxygen species play a significant role in the pathogenesis of retinopathy in diabetes patients. The current study aimed to assess the effect of ethyl acetate extract (EAE) from Balanites aegyptiaca (10, 25 or 50 mg/kg b.w.) in experimental diabetic rats. To achieve this aim, five groups of male rats were included: control, diabetic, and diabetic rats treated with 10, 25, and 50 µg/kg b.w. of EAE for eight weeks. Our results suggests a protective role of EAE against oxidative stress induced by streptozocine. EAE treatment produced a reduction in blood glucose levels, HbA1c, malondialdehyde and vascular endothelial growth factor (VEGF) in diabetic retina (p &lt<br />0.001), as well as an enhancement in antioxidant capacity against streptozocine-induced oxidative stress. Tumor necrosis factor alpha (TNF-α), interleukin (IL-1β) and vascular endothelial growth factor (VEGF) were significantly reduced in diabetic rats treated with EAE, compared with untreated diabetic rats. Analysis of EAE by GC-MS indicated the presence of β-sistosterol. Overall, EAE modulates oxidative stress induced by streptozocine and enhances antioxidant activity, which may provide additional endothelial protection in retina of diabetic rats. These results hold great promise in the management of diabetic complications.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
inflammatory cytokines
Pharmaceutical Science
Acetates
medicine.disease_cause
Article
Diabetes Mellitus, Experimental
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Internal medicine
Diabetes mellitus
Drug Discovery
medicine
Animals
Balanites aegyptiaca
Balanites
Physical and Theoretical Chemistry
chemistry.chemical_classification
Reactive oxygen species
ethyl acetate extract
Diabetic Retinopathy
Dose-Response Relationship, Drug
Plant Extracts
business.industry
antidiabetic
Organic Chemistry
Interleukin
Diabetic retinopathy
medicine.disease
Malondialdehyde
Rats
Vascular endothelial growth factor
Disease Models, Animal
Oxidative Stress
Endocrinology
chemistry
Chemistry (miscellaneous)
Hyperglycemia
Molecular Medicine
Reactive Oxygen Species
business
Oxidative stress
Retinopathy
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 20
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....486acc10b183db81d3c89fc715e77eff