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Fatty acidābinding protein 5 controls lung tumor metastasis by regulating the maturation of natural killer cells in the lung
- Source :
- FEBS Letters. 595:1797-1805
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and is strongly correlated with tumor growth, development, and metastasis. However, it is unclear how the expression of FABP5 in the host affects tumor progression. In this study, using a lung tumor metastasis model in mice, we found that FABP5-deficient mice were more susceptible to tumor metastasis, which is accompanied by infiltration of a lower frequency of activated natural killer (NK) cells in the lung. Additionally, FABP5 deficiency leads to impaired maturation of NK cells in the lungs, but not in the bone marrow and spleen. Taken together, our results provide the first evidence that FABP5 in the host regulates lung tumor metastasis through controlling NK cell maturation.
- Subjects :
- Lung Neoplasms
Biophysics
Spleen
Biology
Fatty Acid-Binding Proteins
Cell Maturation
Biochemistry
Fatty acid-binding protein
Metastasis
Mice
03 medical and health sciences
Lymphocytes, Tumor-Infiltrating
Structural Biology
Cell Line, Tumor
Genetics
medicine
Animals
Lung
Melanoma
Molecular Biology
030304 developmental biology
0303 health sciences
030302 biochemistry & molecular biology
Cell Biology
Lipid Metabolism
medicine.disease
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
Killer Cells, Natural
medicine.anatomical_structure
Tumor progression
Gene Knockdown Techniques
Cancer research
Bone marrow
Infiltration (medical)
Neoplasm Transplantation
Transcription Factors
Subjects
Details
- ISSN :
- 18733468 and 00145793
- Volume :
- 595
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....4868144cf30a7bbcb7abe3e0686a465a