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Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival
Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival
- Source :
- Breast Cancer: Basic and Clinical Research, Vol 13 (2019), Breast Cancer : Basic and Clinical Research
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- Background/Methods: This study determines the co-expression of mammaglobin-A, vascular endothelial growth factor receptor-3 (VEGFR3) and Ki67 by immunohistochemistry (IHC) in tissue samples from 80 patients undergoing breast surgery (cancer or benign disease). The tissue expression was compared with the tumour histopathology and Kaplan Meier 5-year survival analysis was performed. Results: Positive breast tissue expression was observed in 53% samples for mammaglobin, 41% Ki67 and 65% VEGFR3 with a significant positive correlation between Ki67 and VEGFR3 co-expression. Ki67 and VEGFR3 expression correlated with the breast tumour grade and Ki67 expression also correlated with oestrogen receptor (ER) status. At 5 years post-operatively, 6/80 patients had died and 3 patients were alive but had cancer recurrence. High Ki67 expression significantly correlated with poor survival (disease-free and overall). Conclusions: In this study, VEGFR3 and Ki67 expression but not mammaglobin-A correlated with breast tumour pathology. Positive Ki67 expression was also associated with a poor 5-year survival outcome.
- Subjects :
- 0301 basic medicine
Cancer Research
Pathology
medicine.medical_specialty
vascular endothelial growth factor (VEGF)
lcsh:RC254-282
03 medical and health sciences
chemistry.chemical_compound
breast cancer
0302 clinical medicine
Mammaglobin
Breast cancer
Mammaglobin-A
medicine
Original Research
biology
business.industry
Cancer
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Vascular endothelial growth factor
030104 developmental biology
Oncology
chemistry
030220 oncology & carcinogenesis
biology.protein
Immunohistochemistry
business
Ki67
Human breast
Subjects
Details
- ISSN :
- 11782234
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Breast Cancer: Basic and Clinical Research
- Accession number :
- edsair.doi.dedup.....48637d222893e8fab108cd8b4921a168
- Full Text :
- https://doi.org/10.1177/1178223419858957