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Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks
- Source :
- Journal of Neuroimmunology, 156(1-2), 31-41, Journal of Neuroimmunology, 156, 31-41, Journal of Neuroimmunology 156 (2004) 1-2, Journal of Neuroimmunology, 156, 1-2, pp. 31-41
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- xCorticotropin-releasing hormone (CRH) is a central mediator in the response to stress, coordinating behavioral, autonomic and neuroendocrine activation. CRH overproduction is implicated in several affective disorders, including major depression, panic-anxiety disorder and anorexia-diseases also associated with altered immune function. We investigated the link between CRH overdrive and immune function using CRH transgenic mice. Following immunization, CRH transgenic mice fail to form germinal centers; chronic glucocorticoid administration recapitulates this effect in wild-type mice. Regulation of germinal centers by glucocorticoids appears to be mediated, in part, through effects on follicular dendritic cells (FDC), providing a novel mechanism by which CRH dysregulation may significantly impair humoral immune responses. (C) 2004 Elsevier B.V. All rights reserved.
- Subjects :
- endocrine system
medicine.medical_specialty
human neutrophils
Corticotropin-Releasing Hormone
Transgene
Immunology
Mice, Transgenic
stress-induced enhancement
Celbiologie en Immunologie
Biology
immunological memory
Mice
chemistry.chemical_compound
Corticotropin-releasing hormone
Immune system
Corticosterone
Internal medicine
antibody-response
medicine
Animals
lymphotoxin beta-receptor
Immunology and Allergy
mediated-immunity
b-cells
Dose-Response Relationship, Drug
Follicular dendritic cells
deficient mice
Germinal center
Cell Differentiation
Germinal Center
splenic microarchitecture
Mice, Inbred C57BL
Endocrinology
Cell Biology and Immunology
nervous system
Neurology
chemistry
WIAS
Organismal Animal Physiology
Tumor necrosis factor alpha
Neurology (clinical)
tumor-necrosis-factor
Dendritic Cells, Follicular
hormones, hormone substitutes, and hormone antagonists
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 156
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....485bee5944b489337248aa68a1deb6ab