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Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Our aim was to investigate if deoxyribonuclease (DNase) 1 is a potential therapeutic agent to reduce pathogenic effects of cigarette smoke exposure in the lung. Cigarette smoke causes protease imbalance with excess production of proteases, which is a key process in the pathogenesis of emphysema. The mechanisms responsible for this effect are not well-defined. Our studies demonstrate both in vitro and in vivo that cigarette smoke significantly increases the expression of neutrophil and macrophage extracellular traps with coexpression of the pathogenic proteases, neutrophil elastase and matrix metalloproteinases 9 and 12. This response to cigarette smoke was significantly reduced by the addition of DNase 1, which also significantly decreased macrophage numbers and lung proteolysis. DNase 1, a treatment currently in clinical use, can diminish the pathogenic effects of cigarette smoke.
- Subjects :
- 0301 basic medicine
Proteases
Neutrophils
lcsh:Medicine
Matrix metalloproteinase
Article
Cigarette Smoking
03 medical and health sciences
0302 clinical medicine
Deoxyribonuclease I
Humans
Sidestream smoke
lcsh:Science
Lung
Emphysema
Multidisciplinary
biology
Chemistry
Macrophages
lcsh:R
Elastase
Deoxyribonuclease
Neutrophil extracellular traps
Protective Factors
030104 developmental biology
Matrix Metalloproteinase 9
030228 respiratory system
Neutrophil elastase
Myeloperoxidase
Proteolysis
Immunology
biology.protein
lcsh:Q
Leukocyte Elastase
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....4853588de49460d7e8e01050b6da1d4f
- Full Text :
- https://doi.org/10.1038/s41598-017-12474-5