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Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin
- Source :
- Journal of nutritional science and vitaminology. 50(6)
- Publication Year :
- 2005
-
Abstract
- Dietary supplementation of conjugated linoleic acids (CLA) is known to have some beneficial effects such as anti-carcinogenic and anti-obesity effects in several animal species, while it also induces insulin resistance and fatty liver, especially in mice. To explore the possible factors responsible for the CLA-induced insulin resistance, we examined the plasma and mRNA expression levels of several adipocytokines, which are likely involved in the regulation of insulin sensitivity, in normal C5 7BL, mildly obese/diabetic KK and morbidly obese/diabetic KKAy mice. Feeding a diet supplemented with 0.5%, CLA oil consisting of 30.5/% c9, t11-CLA and 28.9% t10, c12-CLA for 4 wk resulted in a decrease in white adipose tissue (WAT), an increase in liver weight with excess accumulation of triglyceride, and insulin resistance associated with hyperglycemia and hyperinsulinemia. The plasma and WAT mRNA levels of leptin were higher in KK and KKAy mice than C57BI. mice, whereas those of adiponectin were higher in C5 7BL mice. CLA-feeding decreased the levels of leptin, adiponectin and resistin, especially in KK and KKAy mice. In contrast, tumor necrosis factor-alpha (TNFalpha) mRNA levels were higher in KK and KKAy mice than C57BL mice, and were increased by CLA feeding. The present results thus indicate that CLA feeding promotes insulin resistance in obese/diabetic mice by at least inverse regulation of leptin and adiponectin, and TNFalpha, adipocytokines known to either ameliorate or deteriorate insulin sensitivity, respectively.
- Subjects :
- Leptin
medicine.medical_specialty
Conjugated linoleic acid
Medicine (miscellaneous)
Adipokine
White adipose tissue
Biology
chemistry.chemical_compound
Mice
Insulin resistance
Dietary Fats, Unsaturated
Internal medicine
medicine
Hyperinsulinemia
Diabetes Mellitus
Animals
Linoleic Acids, Conjugated
Resistin
Obesity
RNA, Messenger
Nutrition and Dietetics
Adiponectin
Tumor Necrosis Factor-alpha
food and beverages
medicine.disease
Mice, Inbred C57BL
Endocrinology
chemistry
Adipose Tissue
Hormones, Ectopic
Intercellular Signaling Peptides and Proteins
lipids (amino acids, peptides, and proteins)
Female
Insulin Resistance
Subjects
Details
- ISSN :
- 03014800
- Volume :
- 50
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of nutritional science and vitaminology
- Accession number :
- edsair.doi.dedup.....48508dfcb2c0cee633f41f9bf547f9c1