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Facile Syntheses of Azetidin-3-ols by Rearrangement of 2,3-Epoxypropylamines

Authors :
Chang Ho Oh
Chul Yun Rhim
Jin Rai Cho
Choong Ho You
Source :
ChemInform. 35
Publication Year :
2004
Publisher :
Wiley, 2004.

Abstract

The N-alkyl-2,3-epoxypropylamines (2) formed from primary alkylamines (1) and epichlorohydrin were chemoselectively rearranged to the four-membered rings, N-alkylazetidin-3-ols (3), upon treatment of triethylamine in refluxing acetonitrile.

Subjects

Subjects :
chemistry.chemical_compound
Primary (chemistry)
chemistry
Organic Chemistry
Organic chemistry
Epichlorohydrin
General Medicine
Acetonitrile
Triethylamine
Medicinal chemistry

Details

ISSN :
15222667 and 09317597
Volume :
35
Database :
OpenAIRE
Journal :
ChemInform
Accession number :
edsair.doi.dedup.....484c57378002bc0ad4561330cd918bf4
Full Text :
https://doi.org/10.1002/chin.200416111
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