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A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling
- Source :
- Oncotarget. 13:944-959
- Publication Year :
- 2022
- Publisher :
- Impact Journals, LLC, 2022.
-
Abstract
- The transcription factor GLI3 is a member of the GLI family and has been shown to be regulated by canonical hedgehog (HH) signaling through smoothened (SMO). Little is known about SMO-independent regulation of GLI3. Here, we identify TLR signaling as a novel pathway regulating GLI3 expression. We show that GLI3 expression is induced by LPS/TLR4 in human monocyte cell lines and peripheral blood CD14
- Subjects :
- Lipopolysaccharides
Tumor Necrosis Factor-alpha
Toll-Like Receptors
NF-kappa B
Nerve Tissue Proteins
Ligands
Toll-Like Receptor 3
Toll-Like Receptor 4
Adaptor Proteins, Vesicular Transport
Mice
Poly I-C
Oncology
Zinc Finger Protein Gli3
Myeloid Differentiation Factor 88
Animals
Cytokines
Humans
Hedgehog Proteins
Interferon Regulatory Factor-3
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....484658c118763b35b72ed76c99c5445f