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Soluble biochemical markers of osteoarthritis: Are we close to using them in clinical practice?
- Source :
- Best practiceresearch. Clinical rheumatology. 31(5)
- Publication Year :
- 2018
-
Abstract
- Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and disability. Recent work suggests that the global burden of OA is increasing, and costs associated with treatment are expected to increase dramatically as the aging human population expands. OA is currently diagnosed using radiography, but this technique is an indirect and insensitive measure of alterations in articular cartilage and fails to measure dynamic inflammatory processes in the joint. Radiographic changes detected overtime are small and occur in only a subset (progressors) of patients with OA. Therefore, we diagnose patients with OA on the basis of a diagnostic classification that is outdated. We also use the same tools and approaches for assessing the efficacy of new pharmacological and nonpharmacological interventions. In this review, we discuss the utility of soluble biochemical markers as biomarkers of OA and discuss whether we are close to using them in clinical practice. Combining patient information, functional imaging and carefully selected panels of biomarkers can help in achieving enhanced patient stratification and lead to better designed clinical trials. Biomarkers can be used for molecular endotyping and for developing more effective and more personalized treatments that will enhance clinical care for patients with OA.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Population
Arthritis
Osteoarthritis
03 medical and health sciences
0302 clinical medicine
Rheumatology
Medicine
Humans
education
Intensive care medicine
Biochemical markers
030203 arthritis & rheumatology
education.field_of_study
business.industry
medicine.disease
3. Good health
Functional imaging
Clinical trial
Clinical Practice
030104 developmental biology
Solubility
Biomarker (medicine)
business
Biomarkers
Subjects
Details
- ISSN :
- 15321770
- Volume :
- 31
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Best practiceresearch. Clinical rheumatology
- Accession number :
- edsair.doi.dedup.....48414b1c34cc77113cb5170de6d541f3