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Effects of Goshajinkigan on insulin resistance in patients with type 2 diabetes
- Source :
- Diabetes research and clinical practice. 69(2)
- Publication Year :
- 2004
-
Abstract
- We investigated the effects of Goshajinkigan (GJG), a Chinese herbal medicine, on insulin sensitivity in patients with type 2 diabetes using the homeostasis model assessment of insulin resistance (HOMA-R) and the euglycemic insulin clamp procedure. Daily oral administration of GJG (7.5 g/day) was performed for 1 month in 71 type 2 diabetes patients: the GJG treatment group. HOMA-Rs were calculated before and after 1 month of GJG treatment and compared with those of 44 controls who were matched in terms of sex, age, body mass index (BMI) and HbA1c levels with the experimental group. In 64 patients out of the GJG treatment group, HOMA-R was calculated 1 month after discontinuation of treatment. In addition, euglycemic clamp was conducted in eight patients before and after the GJG treatment. HOMA-R was 4.78 ± 0.37 (means ± S.E.) before GJG treatment and significantly decreased to 4.02 ± 0.25 after GJG treatment (P = 0.019). No significant change was observed in the control group. HOMA-R returned to the pre-treatment level (P = 0.018) 1 month after GJG treatment discontinuation. Glucose infusion rates and metabolic clearance rates determined by the high-dose euglycemic clamp increased after 1 month of GJG treatment (from 9.6 ± 1.1 to 11.1 ± 0.7 mg/kg/min, P = 0.045 and from 7.9 ± 0.8 to 9.1 ± 0.8 ml/kg/min, P = 0.046, respectively). These results indicate that GJG administration might be useful for improving insulin resistance in patients with type 2 diabetes.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Urology
Type 2 diabetes
Models, Biological
Body Mass Index
Endocrinology
Insulin resistance
Oral administration
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Homeostasis
Humans
In patient
Glycated Hemoglobin
business.industry
General Medicine
Middle Aged
medicine.disease
Discontinuation
Goshajinkigan
Diabetes Mellitus, Type 2
Female
Insulin Resistance
business
Body mass index
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 01688227
- Volume :
- 69
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Diabetes research and clinical practice
- Accession number :
- edsair.doi.dedup.....48401a9efdf9d1d801aebed5fe61ef74