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Effects of immersive virtual reality for preventing and managing anxiety, nausea and vomiting among paediatric cancer patients receiving their first chemotherapy: A study protocol for an exploratory trial
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 10, p e0258514 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- Background Anxiety, nausea and vomiting are common side effects suffered by paediatric patients receiving chemotherapy. Emerging evidence supports the efficacy of immersive virtual reality (IVR) on improving anxiety and distress symptoms including nausea and vomiting among this vulnerable group. This trial aims to assess the feasibility and acceptability of IVR for preventing and managing anxiety, nausea and vomiting among paediatric cancer patients receiving their first chemotherapy. Method and analysis An exploratory trial supplemented by qualitative methods will be conducted. We will recruit 20 paediatric patients who are aged between 6 and 12 years, chemotherapy naïve, scheduled to receive their first intravenous chemotherapy and able to understand Chinese. Participants will be randomly allocated to intervention or control groups. The intervention group will receive the IVR intervention for three sessions as follows: 4 hours before chemotherapy, 5 minutes before and during their first course chemotherapy and 5 minutes before and during their second course chemotherapy. The control group will receive standard care only. Main outcome measures included (1) key parameters for the design of a definitive trial (i.e. screening, eligibility, consent and withdrawal rates); (2) anxiety, anticipatory and acute chemotherapy-induced nausea and vomiting for collection of preliminary data; (3) feasibility and acceptability of the intervention. Semi-structured interviews will be conducted with patients, parents and oncology nurses. Generalized estimating equations model will be used to compare each of the outcome measures across the time points between the two groups. Qualitative data will be analysed by conventional content analysis. Expected results The results of this exploratory trial will inform the design and conduct of future definitive trial. Trial registration number ChiCTR1900021694; Pre-results.
- Subjects :
- Physiology
medicine.medical_treatment
Health Care Providers
Cancer Treatment
Nurses
Blood Pressure
Personal Satisfaction
Anxiety
Pediatrics
Study Protocol
Heart Rate
Neoplasms
Surveys and Questionnaires
Medicine and Health Sciences
Medical Personnel
Child
Multidisciplinary
Pharmaceutics
Virtual Reality
Nausea
Distress
Professions
Oncology
Caregivers
Vomiting
Medicine
medicine.symptom
Clinical Oncology
medicine.medical_specialty
Science
MEDLINE
Antineoplastic Agents
Interviews as Topic
Cancer Chemotherapy
Signs and Symptoms
Drug Therapy
Intervention (counseling)
medicine
Chemotherapy
Humans
business.industry
Biology and Life Sciences
Cancers and Neoplasms
Health Care
People and Places
Physical therapy
Population Groupings
Clinical Medicine
business
Physiological Processes
Qualitative research
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....4838f31851749643526970b484324f0a