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Durable Response to Pazopanib in Recurrent Metastatic Carotid Body Paraganglioma
- Source :
- Case Reports in Oncology, Case Reports in Oncology, Vol 13, Iss 3, Pp 1227-1231 (2020)
- Publication Year :
- 2020
- Publisher :
- S. Karger AG, 2020.
-
Abstract
- We present the case of a 26-year-old woman living at a high altitude diagnosed initially with nonfamilial and nonsecretory localized carotid body tumor managed with surgery, which developed into a recurrent metastatic tumor treated with cyclophosphamide, vincristine, and dacarbazine. The patient continued to progress and developed a left carotid artery thrombosis and worsening of her systemic symptoms. The patient was re-evaluated, and she decided on no further surgery or systemic therapy. DOTATATE positron emission tomography/computed tomography showed widespread somatostatin-avid disease involving the left carotid bulb mass, bilateral lung nodules, and liver metastases, with the largest in the right hepatic lobe measuring 8 × 7 cm. There were peripancreatic lymph nodes and scattered skeletal metastases. The patient sought a second opinion, on the basis of which she was prescribed pazopanib, to which she showed a dramatic clinical response after 1 month, followed by a durable response for 1 year. Tyrosine kinase inhibitors such as pazopanib are potentially useful in paraganglioma, with further studies needed to understand the role of vascular endothelial growth factor receptor-directed kinase inhibitors in this setting.
- Subjects :
- medicine.medical_specialty
Vincristine
Kinase inhibitor
medicine.diagnostic_test
business.industry
Dacarbazine
Pazopanib
Carotid body paraganglioma
Carotid Artery Thrombosis
Case Report
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Carotid Body Paraganglioma
lcsh:RC254-282
medicine.anatomical_structure
Oncology
Positron emission tomography
Paraganglioma
medicine
Carotid body
Radiology
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16626575
- Volume :
- 13
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Case Reports in Oncology
- Accession number :
- edsair.doi.dedup.....4824eb29e8fa3ccb20685025d72898d8