Back to Search
Start Over
New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae
- Source :
- Antimicrobial Agents and Chemotherapy. 61
- Publication Year :
- 2017
- Publisher :
- American Society for Microbiology, 2017.
-
Abstract
- Pharmacodynamics of a polymyxin B, meropenem, and rifampin triple combination were examined against Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) ST258. In time-kill experiments against three KPC-Kp isolates, triple combination generated 8.14, 8.19, and 8.29 log 10 CFU/ml reductions within 24 h. In the hollow-fiber infection model, the triple combination caused maximal killing of 5.16 log 10 CFU/ml at 78 h and the time required for regrowth was more than doubled versus the 2-drug combinations. Remarkably, combinations with a high single-dose polymyxin B burst plus rifampin preserved KPC-Kp polymyxin susceptibility (MIC 240 h = 0.5 mg/liter) versus the same combination with traditionally dosed polymyxin B, where resistance was amplified (MIC 240 h = 32 mg/liter).
- Subjects :
- 0301 basic medicine
medicine.drug_class
Klebsiella pneumoniae
Polymyxin
030106 microbiology
Antibiotics
Colony Count, Microbial
Biological Availability
Microbial Sensitivity Tests
Drug resistance
Meropenem
Drug Administration Schedule
Microbiology
03 medical and health sciences
polycyclic compounds
medicine
Humans
Drug Dosage Calculations
Pharmacology (medical)
Polymyxin B
Pharmacology
Models, Statistical
biology
Chemistry
Drug Synergism
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
Anti-Bacterial Agents
Klebsiella Infections
Infectious Diseases
Area Under Curve
Pharmacodynamics
Drug Therapy, Combination
Thienamycins
Rifampin
Rifampicin
medicine.drug
Subjects
Details
- ISSN :
- 10986596 and 00664804
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Antimicrobial Agents and Chemotherapy
- Accession number :
- edsair.doi.dedup.....481d5769e4d29a4f2d51e95a6480783f