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Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial
- Source :
- Fertility and sterility. 105(4)
- Publication Year :
- 2015
-
Abstract
- Objective To evaluate if antimullerian hormone (AMH) is associated with pregnancy loss. Design Prospective cohort study within a block-randomized, double-blind, placebo-controlled trial of low-dose aspirin. Setting Not applicable. Patient(s) Women (n = 1,228) were of ages 18–40 years with a history of one to two pregnancy losses and were actively attempting pregnancy without fertility treatment. Intervention(s) Not applicable. Main Outcome Measure(s) Pregnancy loss. Result(s) Relative risks (and 95% confidence interval [CIs]) of human chorionic gonadotropin (hCG)-detected and clinical pregnancy loss were assessed with the use of log binomial models with robust variance and inverse probability weights adjusted for age, race, body mass index, income, trial treatment assignment, parity, number of previous losses, and time since most recent loss. AMH levels were defined as: low ( 3.5 ng/mL; n=483). Of the 1,202 women with baseline AMH data, 19 (17.3%) with low AMH experienced a clinical loss, compared with 61 (11.4%) with normal AMH and 50 (11.8%) with high AMH levels. Low or high AMH levels, compared with normal AMH, were not associated with clinical loss. Results for hCG-detected pregnancy loss mirrored those of clinical loss. Conclusion(s) AMH values were not associated with hCG-detected or clinical pregnancy loss in unassisted conceptions in women with a history of one to two previous losses. Our data do not support routine AMH testing for prediction of pregnancy loss. Clinical Trial Registration Number NCT00467363.
- Subjects :
- Adult
Anti-Mullerian Hormone
endocrine system
medicine.medical_specialty
Adolescent
Pregnancy Rate
media_common.quotation_subject
Fertility
Article
Miscarriage
Cohort Studies
03 medical and health sciences
Young Adult
0302 clinical medicine
Double-Blind Method
Pregnancy
medicine
Humans
030212 general & internal medicine
Prospective Studies
Prospective cohort study
media_common
Gynecology
030219 obstetrics & reproductive medicine
Aspirin
urogenital system
Obstetrics
business.industry
Reproduction
Obstetrics and Gynecology
medicine.disease
Confidence interval
Abortion, Spontaneous
Reproductive Medicine
Relative risk
Gestation
Female
business
Body mass index
hormones, hormone substitutes, and hormone antagonists
Biomarkers
Subjects
Details
- ISSN :
- 15565653
- Volume :
- 105
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Fertility and sterility
- Accession number :
- edsair.doi.dedup.....480fa7db3417284b2199a1d5ed6e1665