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Brain atrophy and lesion load predict long term disability in multiple sclerosis

Brain atrophy and lesion load predict long term disability in multiple sclerosis

Authors :
Alex Rovira
Olga Ciccarelli
Giancarlo Comi
Federica Agosta
Nicola De Stefano
Maria Pia Sormani
Philipp Eisele
Stefan Ropele
Declan T. Chard
Jaqueline Palace
Xavier Montalban
Chris H. Polman
Antonio Giorgio
Dirk L. Knol
Frederik Barkhof
Massimo Filippi
Benedetta Bodini
Hanneke E. Hulst
I.C. Sluimer
Veronica Popescu
Bernard M. J. Uitdehaag
Achim Gass
Z Khaleeli
Julio Alonso
Jaume Sastre-Garriga
Christian Enzinger
Hugo Vrenken
Maria Josè Messina
Lucy Matthews
Popescu, V
Agosta, F
Hulst, He
Sluimer, Ic
Knol, Dl
Sormani, Mp
Enzinger, C
Ropele, S
Alonso, J
Sastre-Garriga, J
Rovira, A
Montalban, X
Bodini, B
Ciccarelli, O
Khaleeli, Z
Chard, Dt
Matthews, L
Palace, J
Giorgio, A
De Stefano, N
Eisele, P
Gass, A
Polman, Ch
Uitdehaag, Bmj
Messina, Mj
Comi, G
Filippi, M
Barkhof, F
Vrenken, H
on behalf of the MAGNIMS Study, Group.
Rocca, MARIA ASSUNTA
Neuroscience Campus Amsterdam - Neuroinflammation
Radiology and nuclear medicine
Anatomy and neurosciences
Epidemiology and Data Science
Neurology
Physics and medical technology
NCA - Neuroinflamation
Source :
Popescu, V, Agosta, F, Hulst, H E, Sluimer, I C, Knol, D L, Sormani, M P, Enzinger, C, Ropele, S, Alonso, J, Sastre-Garriga, J, Rovira, A, Montalban, X, Bodini, B, Ciccarelli, O, Khaleeli, Z, Chard, D T, Matthews, L, Palace, J, Giorgio, A, De Stefano, N, Eisele, P, Gass, A, Polman, C H, Uitdehaag, B M J, Messina, M J, Comi, G, Filippi, M, Barkhof, F & Vrenken, H 2013, ' Brain atrophy and lesion load predict long term disability in multiple sclerosis ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 84, no. 10, pp. 1082-1091 . https://doi.org/10.1136/jnnp-2012-304094, Journal of Neurology, Neurosurgery and Psychiatry, 84(10), 1082-1091. BMJ Publishing Group
Publication Year :
2013

Abstract

Objective To determine whether brain atrophy and lesion volumes predict subsequent 10 year clinical evolution in multiple sclerosis (MS). Design From eight MAGNIMS (MAGNetic resonance Imaging in MS) centres, we retrospectively included 261 MS patients with MR imaging at baseline and after 1–2 years, and Expanded Disability Status Scale (EDSS) scoring at baseline and after 10 years. Annualised whole brain atrophy, central brain atrophy rates and T2 lesion volumes were calculated. Patients were categorised by baseline diagnosis as primary progressive MS (n=77), clinically isolated syndromes (n=18), relapsing–remitting MS (n=97) and secondary progressive MS (n=69). Relapse onset patients were classified as minimally impaired (EDSS=0–3.5, n=111) or moderately impaired (EDSS=4–6, n=55) according to their baseline disability (and regardless of disease type). Linear regression models tested whether whole brain and central atrophy, lesion volumes at baseline, follow-up and lesion volume change predicted 10 year EDSS and MS Severity Scale scores. Results In the whole patient group, whole brain and central atrophy predicted EDSS at 10 years, corrected for imaging protocol, baseline EDSS and disease modifying treatment. The combined model with central atrophy and lesion volume change as MRI predictors predicted 10 year EDSS with R 2 =0.74 in the whole group and R 2 =0.72 in the relapse onset group. In subgroups, central atrophy was predictive in the minimally impaired relapse onset patients (R 2 =0.68), lesion volumes in moderately impaired relapse onset patients (R 2 =0.21) and whole brain atrophy in primary progressive MS (R 2 =0.34). Conclusions This large multicentre study points to the complementary predictive value of atrophy and lesion volumes for predicting long term disability in MS.

Details

Language :
English
ISSN :
00223050
Database :
OpenAIRE
Journal :
Popescu, V, Agosta, F, Hulst, H E, Sluimer, I C, Knol, D L, Sormani, M P, Enzinger, C, Ropele, S, Alonso, J, Sastre-Garriga, J, Rovira, A, Montalban, X, Bodini, B, Ciccarelli, O, Khaleeli, Z, Chard, D T, Matthews, L, Palace, J, Giorgio, A, De Stefano, N, Eisele, P, Gass, A, Polman, C H, Uitdehaag, B M J, Messina, M J, Comi, G, Filippi, M, Barkhof, F & Vrenken, H 2013, ' Brain atrophy and lesion load predict long term disability in multiple sclerosis ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 84, no. 10, pp. 1082-1091 . https://doi.org/10.1136/jnnp-2012-304094, Journal of Neurology, Neurosurgery and Psychiatry, 84(10), 1082-1091. BMJ Publishing Group
Accession number :
edsair.doi.dedup.....48094bb4cedf575830ec4af121f65396
Full Text :
https://doi.org/10.1136/jnnp-2012-304094