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Rise and fall of elastic fibers from development to aging. Consequences on arterial structure-function and therapeutical perspectives
- Source :
- Matrix Biology, Matrix Biology, Elsevier, 2019, 84, pp.41-56. ⟨10.1016/j.matbio.2019.08.005⟩, Matrix Biology, 2019, 84, pp.41-56. ⟨10.1016/j.matbio.2019.08.005⟩
- Publication Year :
- 2019
-
Abstract
- In the arteries of vertebrates, evolution has given rise to resilient macromolecular structures, elastin and elastic fibers, capable of sustaining an elevated blood pressure and smoothening the discontinuous blood flow and pressure generated by the heart. Elastic fibers are produced only during development and childhood, before being progressively degraded by mechanical stress and enzymatic activities during adulthood and aging. During this period, arterial elastic fiber calcification and loading of lipids also occur, all of these events conducting to arteriosclerosis. This leads to a progressive dysfunction of the large elastic arteries inducing elevated blood pressure as well as altered hemodynamics and organ perfusion, which induce more global malfunctions of the body during normal aging. Additionally, some arterial conditions occur more frequently with advancing age, such as atherosclerosis or aneurysms, which are called age-related diseases or pathological aging. The physiological or pathological degradation of elastic fibers and function of elastic arteries seemed to be rather inevitable over time. However, during the recent years, different molecules - including several ATP-dependent potassium channel openers, such as minoxidil - have been shown to re-induce elastin production and elastic fiber assembly, leading to improvements in the arterial structure and function or in organ perfusion. This review summarizes the changes in the arterial elastic fibers and structure from development until aging, and presents some of the potential pharmacotherapies leading to elastic fiber neosynthesis and arterial function improvement.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Aging
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Hemodynamics
Elastic fiber assembly
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Internal medicine
medicine
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Animals
Humans
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
Molecular Biology
ComputingMilieux_MISCELLANEOUS
biology
Chemistry
Blood flow
Arteriosclerosis
Arteries
medicine.disease
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Elastin
Extracellular Matrix
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
biology.protein
Cardiology
Minoxidil
Stress, Mechanical
Perfusion
Elastic fiber
Calcification
Subjects
Details
- ISSN :
- 15691802 and 0945053X
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- Matrix biology : journal of the International Society for Matrix Biology
- Accession number :
- edsair.doi.dedup.....4801a35e4b50900189d92f2999bcbddf