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Oral nicorandil for prevention of cardiac death in hemodialysis patients without obstructive coronary artery disease: a propensity-matched patient analysis
- Source :
- Nephron. Clinical practice. 119(4)
- Publication Year :
- 2011
-
Abstract
- Background/Aims: We examined the potential of oral administration of nicorandil for protecting against cardiac death in hemodialysis patients without obstructive coronary artery disease. Methods: This study was based on a cohort study of 155 hemodialysis patients with angiographic absence of obstructive coronary lesions, with analysis performed in 100 propensity-matched patients (54 men and 46 women, 64 ± 10 years), including 50 who received oral administration of nicorandil (15 mg/day, nicorandil group) and 50 who did not (control). The efficacy of nicorandil in preventing cardiac death was investigated. Results: Over a mean follow-up period of 5.3 ± 1.9 years, we observed 25 cardiac deaths among 100 propensity-matched patients, including 6 due to acute myocardial infarction, 11 due to heart failure, and 8 due to sudden cardiac death. The incidence of cardiac death was lower (p < 0.001) in the nicorandil group (4/50, 8%) than in the control (21/50, 42%). On multivariate Cox hazard analysis, cardiac death was inversely associated with oral nicorandil (hazard ratio, 0.123; p = 0.0002). On Kaplan-Meier analysis, cardiac death-free survival rates at 5 years were higher in the nicorandil group than in the control group (91.4 vs. 66.4%). Conclusion: Oral nicorandil may inhibit cardiac death of hemodialysis patients without obstructive coronary artery disease.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Myocardial Infarction
Administration, Oral
Coronary Disease
Kaplan-Meier Estimate
Coronary Angiography
Sudden death
Coronary artery disease
Renal Dialysis
Internal medicine
mental disorders
medicine
Humans
Myocardial infarction
Nicorandil
Aged
Proportional Hazards Models
Retrospective Studies
Heart Failure
Tomography, Emission-Computed, Single-Photon
business.industry
Microangiopathy
Cardiovascular Agents
General Medicine
Middle Aged
medicine.disease
medicine.anatomical_structure
Death, Sudden, Cardiac
Nephrology
Heart failure
cardiovascular system
Cardiology
Drug Evaluation
Kidney Failure, Chronic
Female
Hemodialysis
Insulin Resistance
business
Artery
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 16602110
- Volume :
- 119
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Nephron. Clinical practice
- Accession number :
- edsair.doi.dedup.....47ed481b0f23037f416b42369c753b9f