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Dysregulated transcriptional responses to SARS-CoV-2 in the periphery
- Source :
- Signal Transduction and Targeted Therapy, Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of the host response to SARS-CoV-2 infection through RNA sequencing of peripheral blood samples from 46 subjects with COVID-19 and directly comparing them to subjects with seasonal coronavirus, influenza, bacterial pneumonia, and healthy controls. Early SARS-CoV-2 infection triggers a powerful transcriptomic response in peripheral blood with conserved components that are heavily interferon-driven but also marked by indicators of early B-cell activation and antibody production. Interferon responses during SARS-CoV-2 infection demonstrate unique patterns of dysregulated expression compared to other infectious and healthy states. Heterogeneous activation of coagulation and fibrinolytic pathways are present in early COVID-19, as are IL1 and JAK/STAT signaling pathways, which persist into late disease. Classifiers based on differentially expressed genes accurately distinguished SARS-CoV-2 infection from other acute illnesses (auROC 0.95 [95% CI 0.92–0.98]). The transcriptome in peripheral blood reveals both diverse and conserved components of the immune response in COVID-19 and provides for potential biomarker-based approaches to diagnosis.
- Subjects :
- 0301 basic medicine
Letter
Science
General Physics and Astronomy
Disease
Biology
Predictive markers
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Transcriptome
Prognostic markers
03 medical and health sciences
0302 clinical medicine
Immune system
Interferon
Influenza, Human
Pneumonia, Bacterial
medicine
Humans
Coronavirus
Multidisciplinary
SARS-CoV-2
Sequence Analysis, RNA
Gene Expression Profiling
Bacterial pneumonia
COVID-19
General Chemistry
biochemical phenomena, metabolism, and nutrition
medicine.disease
Gene expression profiling
030104 developmental biology
030220 oncology & carcinogenesis
Host-Pathogen Interactions
Immunology
Leukocytes, Mononuclear
Cytokines
Infectious diseases
Signal transduction
Systems biology
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....47e61cde0bcc5db49576e7b736d3272e