Back to Search
Start Over
The association between keloid and osteoporosis: real-world evidence
- Source :
- BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-9 (2021), BMC Musculoskeletal Disorders
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background Keloids are characterized by disturbance of fibroblast proliferation and apoptosis, deposition of collagen, and upregulation of dermal inflammation cells. This benign dermal fibro-proliferative scarring condition is a recognized skin inflammation disorder. Chronic inflammation is a well-known contributor to bone loss and its sequelae, osteoporosis. They both shared a similar pathogenesis through chronic inflammation. We assessed whether keloids increase osteoporosis risk through using National Health Insurance Research Database. Methods The 42,985 enrolled patients included 8597 patients with keloids but no history of osteoporosis; 34,388 controls without keloids were identified from the general population and matched at a one-to-four ratio by age, gender. Kaplan-Meier method was applied to determine cumulative incidence of osteoporosis. Cox proportional hazard regression analysis was performed after adjustment of covariates to estimate the effect of keloids on osteoporosis risk. Results Of the 8597 patients with keloids, 178 (2.07%) patients were diagnosed with osteoporosis while in the 34,388 controls, 587 (1.71%) were diagnosed with osteoporosis. That is, the keloids patients had 2.64-fold higher risk of osteoporosis compared to controls after adjustment for age, gender, Charlson Comorbidity Index and related comorbidities. The association between keloids and osteoporosis was strongest in patients younger than 50 years (hazard ratio = 7.06%) and in patients without comorbidities (hazard ratio = 4.98%). In the keloids patients, a high incidence of osteoporosis was also associated with advanced age, high Charlson Comorbidity Index score, hyperlipidemia, chronic liver disease, stroke, and depression. Conclusions Osteoporosis risk was higher in patients with keloids compared to controls, especially in young subjects and subjects without comorbidities.
- Subjects :
- medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Epidemiology
Population
Osteoporosis
Comorbidity
Chronic liver disease
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Rheumatology
Internal medicine
medicine
Humans
Orthopedics and Sports Medicine
Cumulative incidence
education
skin and connective tissue diseases
Depression (differential diagnoses)
Population-based study
Inflammation
education.field_of_study
business.industry
Incidence
Incidence (epidemiology)
Hazard ratio
medicine.disease
030220 oncology & carcinogenesis
Keloid
Collagen
lcsh:RC925-935
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712474
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Musculoskeletal Disorders
- Accession number :
- edsair.doi.dedup.....47e48596f9c160a210393367d0c2110b