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Risk of ocular hypertension in children treated with systemic glucocorticoid
- Source :
- Krag, S, Larsen, D, Albertsen, B K & Glerup, M 2021, ' Risk of ocular hypertension in children treated with systemic glucocorticoid ', Acta Ophthalmologica, vol. 99, no. 8, pp. e1430-e1434 . https://doi.org/10.1111/aos.14820
- Publication Year :
- 2021
-
Abstract
- Purpose: To investigate the risk of steroid-induced ocular hypertension in children treated with systemic glucocorticoid. Methods: Prospective cohort study of children treated with high-dose systemic glucocorticoid (prednisolone-equivalent >0.5 mg/kg/day) for more than 2 weeks. Intraocular pressure (IOP) was measured by an Icare tonometer. An intraocular hypertensive response was defined as a net increase in IOP ≥6 mmHg from baseline or a peak IOP ≥21 mmHg in either eye. Patients with a peak IOP ≥31 mmHg or a net increase in IOP ≥15 mmHg were considered as high responders. Results: Sixteen children with median age 12 years (range 5–17) were included in the study. Nine children (56%) developed a steroid-induced ocular hypertensive response. Two children (12%) were high responders with peak IOP between 32 and 44 mmHg and a net increase in IOP between 15 and 23 mmHg. All children were asymptomatic and IOP was normalized in all after withdrawal of steroid. Steroid responders were significantly younger than nonresponders (p = 0.03). No associations were found between net IOP increase and time to peak pressure, steroid dose at peak pressure or accumulated prednisolone dose at peak IOP. Conclusion: Systemic treatment of children with glucocorticoid can cause a significant increase in IOP which indicates the need for IOP screening of these children. The risk of steroid-induced ocular hypertension may depend on age and ethnicity. In this perspective, further studies on Caucasian children are needed.
- Subjects :
- Male
Intraocular pressure
High responder
Time Factors
Adolescent
genetic structures
Denmark
Prednisolone
Ocular hypertension
Glaucoma
Asymptomatic
Dexamethasone
03 medical and health sciences
Tonometry, Ocular
0302 clinical medicine
children
Medicine
Humans
Prospective Studies
Prospective cohort study
Child
Glucocorticoids
Intraocular Pressure
Dose-Response Relationship, Drug
business.industry
Incidence
screening
steroid
Infant, Newborn
Infant
General Medicine
medicine.disease
eye diseases
Ophthalmology
glaucoma
Anesthesia
Child, Preschool
030221 ophthalmology & optometry
ocular hypertension
Female
Ocular Hypertension
sense organs
medicine.symptom
business
030217 neurology & neurosurgery
Glucocorticoid
medicine.drug
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Krag, S, Larsen, D, Albertsen, B K & Glerup, M 2021, ' Risk of ocular hypertension in children treated with systemic glucocorticoid ', Acta Ophthalmologica, vol. 99, no. 8, pp. e1430-e1434 . https://doi.org/10.1111/aos.14820
- Accession number :
- edsair.doi.dedup.....47e2a87cfb6e51501708e0425ad90a6d