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The Effect of PM 10 on Ischemia- Reperfusion Induced Arrhythmias in Rats
- Source :
- Brazilian Archives of Biology and Technology, Vol 59, Iss 0, Brazilian Archives of Biology and Technology, Volume: 59, Article number: e16160132, Published: 28 JUL 2016, Brazilian Archives of Biology and Technology v.59 2016, Brazilian Archives of Biology and Technology, Instituto de Tecnologia do Paraná (Tecpar), instacron:TECPAR
- Publisher :
- Instituto de Tecnologia do ParanĂ¡ (Tecpar)
-
Abstract
- Epidemiological studies show that particulate matter (PM) is the principal instigator of some adverse clinical symptoms involving cardiovascular diseases. PM exposure can increase experimental infarct size and potentiate myocardial ischemia and arrhythmias in experimental MI models such as ischemia-reperfusion (I/R) injury.The present study was aimed to evaluate the effects of particulate matter (PM10) on ischemia- reperfusion induced arrhythmias with emphasis on the protective role of VA as an antioxidant on them. Male Wistar rats were divided into 8 groups (n=10): Control, VAc, Sham, VA, PM1 (0.5 mg/kg), PM2 (2.5 mg/kg), PM3 group (5 mg/kg), PM3 + VA group. Within 48 hours, PM10 was instilled into trachea in two stages. Then the hearts were isolated, transferred to a Langendorff apparatus, and subjected to global ischemia (30 minutes) followed by reperfusion (60 minutes). The ischemia- reperfusion induced ventricular arrhythmias were assessed according to the Lambeth conventions.In the present study,the number, incidence and duration of arrhythmiasduring30 minutes ischemia were demonstrated to be more than those in the reperfusion stage. PM exposure increased significantly the number, incidence and duration of arrhythmias in the ischemia and reperfusion duration. Vanillic acid reduced significantly the number, incidence and duration of arrhythmias during the ischemia and reperfusion period.In summary, the results of this study demonstrated that the protective and dysrhythmic effects of VA in the PM exposure rats in I/R model are probably related to its antioxidant properties.
- Subjects :
- medicine.medical_specialty
Antioxidant
Myocardial ischemia
010504 meteorology & atmospheric sciences
medicine.medical_treatment
lcsh:Biotechnology
Ischemia
010501 environmental sciences
01 natural sciences
Two stages
Internal medicine
lcsh:TP248.13-248.65
medicine
cardiovascular diseases
0105 earth and related environmental sciences
Multidisciplinary
business.industry
arrhythmias,Vanillic Acid
medicine.disease
Infarct size
Particullate Matter
Ischemia- reperfusion
Cardiology
Rat
business
Subjects
Details
- Language :
- English
- ISSN :
- 16784324
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Brazilian Archives of Biology and Technology
- Accession number :
- edsair.doi.dedup.....47d1b33a2a81eaa9bf365a8b9f8db820